2-(10-undecenyl-1-oxy)ethanol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(10-undecenyl-1-oxy)ethanol
• 英文别名: 2-Undec-10-enoxyethanol
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.348
• InChiKey: BZJRYAVERLTENL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(10-undecenyl-1-oxy)ethanol 在 四氧化锇 作用下， 生成 11-(2-hydroxyethoxy)undecane-1,2-diol
  参考文献：
  名称：

  Hentrich, Frank; Tschierske, Carsten; Zaschke, Horst, Angewandte Chemie, 1991, vol. 103, # 4, p. 429 - 431

  摘要：

  DOI：
• 作为产物：
  描述：

  10-十一烯-1-醇 在 N-溴代丁二酰亚胺(NBS) 、 sodium hydride 、 三苯基膦 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 28.0h， 生成 2-(10-undecenyl-1-oxy)ethanol
  参考文献：
  名称：

  ALKYL SULFATE ESTER OR SALT OF SAME

  摘要：

  一种含有羰基基团或其盐的烷基硫酸酯化合物，其化学式如下：R1—C(═O)—(CR22)n—(OR3)p(CR42)q-L-OSO3X，其中R1、R2、R3、R4、L、X、n、p和q的定义如本文所述。还公开了制备烷基硫酸酯的方法。

  公开号：

  US20200399211A1

文献信息

• Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers
  作者：Kevin L. Prime、George M. Whitesides

  DOI：10.1021/ja00076a032

  日期：1993.11

  This paper reports a study of the adsorption of four proteins-fibrinogen, lysozyme, pyruvate kinase, and RNAse A-to self-assembled monolayers (SAMs) on gold. The SAMs examined were derived from thiols of the structure HS(CH 2 ) 10 R, where R was CH 3 , CH 2 OH, and oligo(ethylene oxide). Monolayers that contained a sufficiently large mole fraction of alkanethiolate groups terminated in oligo(ethylene oxide)

  本文报告了四种蛋白质 - 纤维蛋白原、溶菌酶、丙酮酸激酶和 RNA 酶 A 对金上自组装单层 (SAM) 的吸附研究。所检查的 SAM 源自结构为 HS(CH 2 ) 10 R 的硫醇，其中 R 是 CH 3 、CH 2 OH 和低聚（环氧乙烷）。含有足够大摩尔分数的链烷烃硫醇基团终止于低聚（环氧乙烷）链的单层抵抗所有四种蛋白质的动力学不可逆、非特异性吸附。较长的低聚（环氧乙烷）链在单层中的较低摩尔分数下具有抗性。对蛋白质吸附的抵抗力随着低聚（环氧乙烷）链的长度而增加：阻止吸附的链的最小摩尔分数与 n -0.4 成正比，其中 n 表示每条链的环氧乙烷单元数
• Factors that Determine the Protein Resistance of Oligoether Self-Assembled Monolayers − Internal Hydrophilicity, Terminal Hydrophilicity, and Lateral Packing Density
  作者：Sascha Herrwerth、Wolfgang Eck、Sven Reinhardt、Michael Grunze

  DOI：10.1021/ja034820y

  日期：2003.8.1

  Protein resistance of oligoether self-assembled monolayers (SAMS) on gold and silver surfaces has been investigated systematically to elucidate structural factors that determine whether a SAM will be able to resist protein adsorption. Oligo(ethylene glycol) (OEG)-, oligo(propylene glycol)-, and oligo(trimethylene glycol)-terminated alkanethiols with different chain lengths and alkyl termination were synthesized as monolayer constituents. The packing density and chemical composition of the SAMS were examined by XPS spectroscopy; the terminal hydrophilicity was characterized by contact angle measurements. IRRAS spectroscopy gave information about the chain conformation of specific monolayers; the amount of adsorbed protein as compared to alkanethiol monolayers was determined by ellipsometry. We found several factors that in combination or by themselves suppress the protein resistance of oligoether monolayers. Monolayers with a hydrophobic interior, such as those containing oligo(propylene glycol), show no protein resistance. The lateral compression of oligo(ethylene glycol) monolayers on silver generates more highly ordered monolayers and may cause decreased protein resistance, but does not necessarily lead to an all-trans chain conformation of the OEG moieties. Water contact angles higher than 70degrees on gold or 65degrees on silver reduce full protein resistance. We conclude that both internal and terminal hydrophilicity favor the protein resistance of an oligoether monolayer. It is suggested that the penetration of water molecules in the interior of the SAM is a necessary prerequisite for protein resistance. We discuss and summarize the various factors which are critical for the functionality of "inert" organic films.
• HENTRICH, FRANK;TSCHIERSKE, CARSTEN;ZASCHKE, HORST, ANGEW. CHEM., 103,(1991) N, C. 429-431
  作者：HENTRICH, FRANK、TSCHIERSKE, CARSTEN、ZASCHKE, HORST

  DOI：——

  日期：——
• Molecules suitable for binding to a metal layer for covalently immobilizing biomolecules
  申请人：Frederix Filip

  公开号：US20070272003A1

  公开（公告）日：2007-11-29

  An article is provided for immobilizing functional organic biomolecules (e.g. proteins, DNA, and the like) through a covalent bond to a thiolate or disulfide monolayer to a metal surface wherein an extra activation step of the surface layer or an activation step of the functional biomolecules or bioreceptors could be avoided. The monolayer can contain, but is not limited to, two moieties. One has a group that resists nonspecific adsorption and another has a group that directly (without activation) reacts with functional groups on the biomolecules. In addition, poly(ethylene oxide) groups are incorporated in the monolayer surfaces to resist the nonspecific adsorption and to enhance the specific affinity interactions. A sensor device including these monolayers is also provided to perform reproducible, sensitive, specific and stable bioanalysis.
• Polar group-containing olefin copolymer, process for preparing the same, thermoplastic resin composition containing the copolymer, and uses thereof
  申请人：Imuta Junichi

  公开号：US20090137757A1

  公开（公告）日：2009-05-28

  A polar group-containing olefin copolymer having excellent adhesion properties to metals or polar resins and excellent compatibility therewith, a process for preparing the copolymer, a thermoplastic resin composition containing the copolymer, and uses thereof. The polar group-containing olefin copolymer comprises a constituent unit derived from an □-olefin of 2 to 20 carbon atoms, and a constituent unit derived from a straight-chain, branched or cyclic polar group-containing monomer having at the end a polar group such as a hydroxyl group or an epoxy group and/or a constituent unit derived from a macromonomer having at the end a polymer segment obtained by anionic polymerization, ring-opening polymerization or polycondensation. The polar group-containing olefin copolymer can be prepared by polymerizing the α-olefin with the polar group-containing monomer and/or the macromonomer in the presence of a metallocene catalyst. The polar group-containing olefin copolymer and the thermoplastic resin composition containing the copolymer are used for films, sheets, modifiers, building/civil engineering materials, automobile exterior trim, electric/electronic parts, coating bases, compatibilizing agents, etc.