Substituted (
<i>E</i>
)‐2‐Methylene‐3,4‐cyclohexenones through Direct and Convenient Synthesis from Cyclohexenone‐MBH Alcohol in the Presence of DMAP
作者:Hong‐Xia Ren、Xiang‐Jia Song、Lin Wu、Zhi‐Cheng Huang、Ying Zou、Xia Li、Xiao‐Wen Chen、Fang Tian、Li‐Xin Wang
DOI:10.1002/ejoc.201801301
日期:2019.1.31
An unexpected new reaction of cyclohexenone‐MBH alcohol catalyzed by DMAP has been successfully disclosed to prepare a series of substituted (E)‐2‐methylene‐3,4‐cyclohexenones in excellent yields (up to 93 %) under convenient reaction conditions. Scale‐up preparation and synthetic transformations have been conducted.
namely 2-(2-furyl)hydroxymethyl-2-cycloalkenones, are reported. The access to these systems is one step using an aqueous Morita–Baylis–Hillman reaction combining hydroxymethylfurfural and glucosyloxymethylfurfural and cycloalkenones for which the reaction conditions (promoter, solvent, concentration, and stoichiometry) have been optimized.
Sequential Morita–Baylis–Hillman/Achmatowicz reactions: an expeditious access to pyran-3(6H)-ones with a unique substitution pattern
作者:Bruno B. Guidotti、Fernando Coelho
DOI:10.1016/j.tetlet.2015.09.120
日期:2015.11
We herein disclosed a novel approach to synthesize densely functionalized 6-hydroxy-2H-pyran-3(6H)-ones with moderate to good diastereoselectivity. The method is based on a two step sequence using Morita-Baylis-Hillman adducts as substrates for the Achmatowicz rearrangement, allowing the preparation of highly substituted pyran-3-ones with overall yields ranging from 17% to 80% and a unique substitution pattern. (C) 2015 Elsevier Ltd. All rights reserved.
Facile synthesis of 2H-indazole derivatives starting from the Baylis–Hillman adducts of 2-cyclohexen-1-one
作者:Ka Young Lee、Saravanan Gowrisankar、Jae Nyoung Kim
DOI:10.1016/j.tetlet.2005.05.149
日期:2005.8
Facile synthetic method of 2H-indazole derivatives was developed involving DDQ oxidation of pyrazoles, which were prepared starting from the Baylis-Hillman adducts of 2-cyclohexen-1-one. (c) 2005 Elsevier Ltd. All rights reserved.