佛波醇12-惕各酸酯13-癸酸酯 | 59086-92-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 佛波醇12-惕各酸酯13-癸酸酯
• 英文名称: Phorbol caprate, tiglate
• 英文别名: [(1S,2S,6R,10S,11R,13S,14R,15R)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-14-[(E)-2-methylbut-2-enoyl]oxy-5-oxo-13-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] decanoate
• CAS: 59086-92-9
• 化学式: C₃₅H₅₂O₈
• 分子量: 600.8
• InChiKey: QWYNFKKVBDGBLL-KFWZAFQTSA-N

物化性质

• 沸点：
  570.75°C (rough estimate)
• 密度：
  1.0676 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Compositions and methods of use of phorbol esters for the treatment of stroke
  申请人：Biosuccess Biotech Co. Ltd.

  公开号：US10010519B2

  公开（公告）日：2018-07-03

  Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.

  本发明提供了含有植物醇酯或植物醇酯衍生物的方法和组合物，用于治疗和预防中风及中风后遗症。此外，还提供了其他组合物和方法，这些组合物和方法采用了与至少一种额外制剂相结合的植物醇酯或衍生物化合物，以产生更有效的治疗工具来治疗或预防哺乳动物中风和中风的长期后遗症。
• Compositions and methods of use of phorbol esters in the treatment of neoplasms
  申请人：Biosuccess Biotech Co. Ltd.

  公开号：US10806714B2

  公开（公告）日：2020-10-20

  Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.

  本发明提供了含有植物醇酯或植物醇酯衍生物的方法和组合物，用于治疗慢性和急性疾病。这些病症可能由疾病引起，也可能是疾病的症状、治疗方法或后遗症。所述的植物醇酯特别适用于治疗肿瘤性疾病和/或控制肿瘤性疾病化疗和放疗的副作用。
• Method of isolating extract from the euphorbaciae obesa plant and methods for using the same
  申请人：Credere Corporation

  公开号：US20030118677A1

  公开（公告）日：2003-06-26

  The present invention is directed to a process of isolating an extract from a Euphorbaciae obesa (EO) plant by: preparing a sample of said plant comprising removal of the latex material; dissolving said sample with first solvent to form a solution; seperating said solution into a liquid and a pulp fraction; and purifying said pulp fraction. The isolated EO extract induces apoptosis and inhibits growth of a cancerous cell. Thus, the present invention is also directed to a method for inducing apoptosis and growth inhibition of a cancerous cell by contacting the cell with an effective amount of the EO extract by the process of the invention. Preferably, the extract is administered both to the tumor directly and intravenously. The preferred lines of cancerous cells are melanoma, non-small cell lung cancer, prostate cancer, breast carcinoma, ovarian cancer, lymphoma and leukemia cells.

  本发明涉及一种从大戟科植物中分离提取物的工艺。 大戟科 (EO)植物中分离提取物的方法：制备所述植物的样品，包括去除乳胶材料；用第一种溶剂溶解所述样品以形成溶液；将所述溶液分离为液体和果肉馏分；以及纯化所述果肉馏分。分离出的环氧乙烷提取物可诱导癌细胞凋亡并抑制其生长。因此，本发明还涉及一种诱导癌细胞凋亡和抑制其生长的方法，该方法通过本发明的工艺将癌细胞与有效量的环氧乙烷提取物接触。优选地，萃取物既可直接施用于肿瘤，也可静脉注射。优选的癌细胞系为黑色素瘤、非小细胞肺癌、前列腺癌、乳腺癌、卵巢癌、淋巴瘤和白血病细胞。
• Euphorbia antiquorum extract, a pharmaceutical composition containing the same and methods for treatment of cancers
  申请人：——

  公开号：US20030165579A1

  公开（公告）日：2003-09-04

  An herbal extract of Euphorbia antiquorum is provided. The herbal extract of the invention demonstrates in vitro inhibition of growth of hepatoma cells, colorectal adenocarcinoma cells, monocyte-like lymphoma and leukemia cells. This invention also provides a pharmaceutical composition containing the same and a method for treatments for cancers.

  的草药提取物 大戟 提供。本发明的草药提取物在体外对肝癌细胞、结直肠腺癌细胞、单核细胞样淋巴瘤和白血病细胞的生长有抑制作用。本发明还提供了一种含有相同成分的药物组合物和一种治疗癌症的方法。
• COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTERS FOR THE TREATMENT OF STROKE
  申请人：BIOSUCCESS BIOTECH CO., LTD

  公开号：US20140011873A1

  公开（公告）日：2014-01-09

  Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.