1-(2-oxopropyl)quinolin-2(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-oxopropyl)quinolin-2(1H)-one
• 英文别名: 1-(2-Oxopropyl)quinolin-2-one
• 化学式: C₁₂H₁₁NO₂
• 分子量: 201.225
• InChiKey: ZDCVQVBLOHDNLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-喹啉醇 、 一氯丙酮 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以67%的产率得到1-(2-oxopropyl)quinolin-2(1H)-one
  参考文献：
  名称：

  STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES

  摘要：

  Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N-1-and O-2-alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro-quinolin-2(1H)-ones under the same reaction conditions gave exclusively O-2-alkylated products.

  DOI：

  10.4067/s0717-97072015000100008

文献信息

• STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES
  作者：CHIA-LING CHEN、I-LI CHEN、JIH-JUNG CHEN、DAU-CHANG WEI、HAN-JIE HSIEH、KEN-MING CHANG、CHERNG-CHYI TZENG、TAI-CHI WANG

  DOI：10.4067/s0717-97072015000100008

  日期：——

  Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N-1-and O-2-alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro-quinolin-2(1H)-ones under the same reaction conditions gave exclusively O-2-alkylated products.