9,9-dimethyl-12-(3-nitrophenyl)-8,9,10,12-tetrahydro-7H-benzo[a]acridin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9,9-dimethyl-12-(3-nitrophenyl)-8,9,10,12-tetrahydro-7H-benzo[a]acridin-11-one
• 英文别名: 3,3-dimethyl-9-(3-nitrophenyl)-1,2,3,4,9,10-hexahydrobenzo[a]acridine-1-one；9,9-dimethyl-12-(3-nitrophenyl)-8,9,10,12-tetrahydrobenzo[a]acridin-11(7H)-one；9,9-dimethyl-12-(3-nitrophenyl)-7,8,10,12-tetrahydrobenzo[a]acridin-11-one
• 化学式: C₂₅H₂₂N₂O₃
• 分子量: 398.461
• InChiKey: IMCSTOUGZDWKJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 、 N-(3-Nitrobenzyliden)-2-aminonaphthalin 在 苄基三乙基氯化铵 作用下， 以 水 为溶剂， 反应 3.0h， 以92%的产率得到9,9-dimethyl-12-(3-nitrophenyl)-8,9,10,12-tetrahydro-7H-benzo[a]acridin-11-one
  参考文献：
  名称：

  三乙基苄基氯化铵在水性介质中催化清洁合成多氢ac啶和茚并喹啉衍生物

  摘要：

  通过N-芳烯萘-2-胺与1,3-二羰基化合物的反应，可以高效合成苯并[ a ] r啶和茚并[1,2- b ]苯并[ f ]喹啉。三乙基苄基氯化铵（TEBAC）在水性介质中。通过光谱数据确定结构，并通过X射线分析进一步确认。该方法具有许多优点，例如中性条件，高收率和简单的后处理程序。另外，选择水作为绿色和可循环使用的溶剂。

  DOI：

  10.1002/jhet.5570430426

文献信息

• An efficient one-pot synthesis of polyhydrobenzoacridine-1-one derivatives under microwave irradiation without catalyst
  作者：Shujiang Tu、Runhong Jia、Bo Jiang、Yan Zhang、Junyong Zhang

  DOI：10.1002/jhet.5570430629

  日期：2006.11

  A series of 3,3-dimethyl-9-substituted-1,2,3,4,9,10-hexahydrobenzo[c] acridine-1-ones and 3,3-dimethyl-9-substituted-1,2,3,4,9,10-hexahydrobenzo[a] acridine-1-ones were synthesized by the reaction of an aldehyde, α-naphthylamine or β-naphthylamine and dimedone under microwave irradiation with short times and high yields.

  一系列3,3-二甲基-9-取代的1,2,3,4,9,10-六氢苯并[ c ] a啶-1-酮和3,3-二甲基-9-取代的1,2,3通过醛，α-萘胺或β-萘胺与二甲酮在微波辐射下短时间，高收率反应合成了4,9,10-六氢苯并[ a ] a啶-1-酮。
• The first example of glucose-containing Brønsted acid synthesis and catalysis: efficient synthesis of tetrahydrobenzo[α]xanthens and tetrahydrobenzo[α]acridines in water
  作者：Yu Wan、Xiao-xiao Zhang、Chao Wang、Ling-ling Zhao、Liang-feng Chen、Gui-xiang Liu、Shu-ying Huang、Shu-ning Yue、Wen-li Zhang、Hui Wu

  DOI：10.1016/j.tet.2013.03.029

  日期：2013.5

  Glucose sulfonic acid (GSA) was synthesized for the first time and used as an efficient catalyst for the preparation of tetrahydrobenzo[alpha]xanthens and tetrahydrobenzo[alpha]acridines via the reaction of aromatic aldehydes, 2-naphthol (or beta-naphthylamine), and dimedone in water. Up to four new bonds and one new ring were formed in one-pot with water as the only by-product in these two reactions. The work opens up a new and efficient synthesis and application of sugar-containing Bronsted acid. (C) 2013 Elsevier Ltd. All rights reserved.