3-methyl-1,3-diphenyl-3,4-dihydrobenzo[f]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-methyl-1,3-diphenyl-3,4-dihydrobenzo[f]quinoline
• 英文别名: 3-methyl-1,3-diphenyl-4H-benzo[f]quinoline
• 化学式: C₂₆H₂₁N
• 分子量: 347.459
• InChiKey: FNIAGYOBBZZGRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙炔 、 2-萘胺 在 indium(III) triflate 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以85%的产率得到3-methyl-1,3-diphenyl-3,4-dihydrobenzo[f]quinoline
  参考文献：
  名称：

  Indium(III)-Catalyzed Tandem Hydroamination–Hydroarylation of Naphthylamines with Phenylacetylenes

  摘要：

  A one-pot, three-component method for the synthesis of benzo-fused quinolines has been developed by tandem reaction between phenylacetylenes and naphthylamines. The first step of the reaction is hydroamination of the alkyne followed by a hydroarylation reaction to form the quinolines. Indium(III) trifluoromethanesulfonate was shown to be an efficient catalyst for the transformations, and the reaction proceeded in the absence of any other co-catalyst or additive to give the corresponding quinolines in good to excellent yields.

  DOI：

  10.1055/s-0033-1341234

文献信息

• Indium(III)-Catalyzed Tandem Hydroamination–Hydroarylation of Naphthylamines with Phenylacetylenes
  作者：Dipak Prajapati、Nimmakuri Rajesh、Rupam Sarma

  DOI：10.1055/s-0033-1341234

  日期：——

  A one-pot, three-component method for the synthesis of benzo-fused quinolines has been developed by tandem reaction between phenylacetylenes and naphthylamines. The first step of the reaction is hydroamination of the alkyne followed by a hydroarylation reaction to form the quinolines. Indium(III) trifluoromethanesulfonate was shown to be an efficient catalyst for the transformations, and the reaction proceeded in the absence of any other co-catalyst or additive to give the corresponding quinolines in good to excellent yields.