N⁴,N⁴-diethyl-N¹-(2-bromo-acridin-9-yl)-1-methyl-butanediyldiamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N⁴,N⁴-diethyl-N¹-(2-bromo-acridin-9-yl)-1-methyl-butanediyldiamine
• 英文别名: N⁴,N⁴-Diaethyl-N¹-(2-brom-acridin-9-yl)-1-methyl-butandiyldiamin；4-N-(2-bromoacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
• 化学式: C₂₂H₂₈BrN₃
• 分子量: 414.388
• InChiKey: OULOHOAQVGYIRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  28.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-bromo-9-chloroacridine 、 2-氨基-5-二乙基氨基戊烷 在 邻甲酚 作用下， 生成 N⁴,N⁴-diethyl-N¹-(2-bromo-acridin-9-yl)-1-methyl-butanediyldiamine
  参考文献：
  名称：

  Basically substituted acridine compounds

  摘要：

  公开号：

  US02077249A1

文献信息

• [EN] PYRIDIN-4-YLAMINE COMPOUNDS USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN<br/>[FR] COMPOSES DE PYRIDIN-4-YLAMINE CONVENANT POUR LE TRAITEMENT DE LA DOULEUR NEUROPATHIQUE
  申请人：MERCK & CO INC

  公开号：WO2005051915A1

  公开（公告）日：2005-06-09

  The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α2δ-1 subunit of Ca channels.

  本发明涉及一种在治疗神经病性疼痛中使用三唑吡啶化合物的方法。本发明还涉及在治疗精神和情绪障碍，如精神分裂症、焦虑、抑郁、躁郁症和恐慌，以及在治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍（如倒班引起的睡眠障碍和时差反应）、药物成瘾、药物滥用、药物戒断和其他疾病中使用三唑吡啶化合物的方法。本发明还涉及选择性结合到Ca通道α2δ-1亚基的新型三唑吡啶化合物。
• Basically substituted acridine compounds
  申请人：WINTHROP CHEM CO INC

  公开号：US02077249A1

  公开（公告）日：1937-04-13