6-[3-(2-methyl-1-imidazolyl)propoxy]-3,4-dihydrocarbostyril

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[3-(2-methyl-1-imidazolyl)propoxy]-3,4-dihydrocarbostyril
• 英文别名: 6-[3-(2-methylimidazol-1-yl)propoxy]-3,4-dihydro-1H-quinolin-2-one
• 化学式: C₁₆H₁₉N₃O₂
• 分子量: 285.346
• InChiKey: ZBEPSYAMQWPLBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  56.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基咪唑 、 6-(3-bromopropoxy)-3,4-dihydro-2(1H)-quinolinone 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 异丙醇 为溶剂， 生成 6-[3-(2-methyl-1-imidazolyl)propoxy]-3,4-dihydrocarbostyril
  参考文献：
  名称：

  Carbostyril derivatives and salts thereof and pharmaceutical composition

  摘要：

  下列一般式所示的碳基喹啉衍生物或其制药可接受的盐：##STR1## 其中Z，A，XN，R，R.sup.1和R.sup.2如规范中所定义。这些碳基喹啉衍生物在制药组合物中用于抑制血小板粘附。

  公开号：

  US05008274A1

文献信息

• Carbostyril derivatives and salts thereof and pharmaceutical
  申请人：Otsuka Pharmaceutical Co. Ltd.

  公开号：US05434164A1

  公开（公告）日：1995-07-18

  Carbostyril derivatives and salts thereof represented by the general formula (1a), including some known compounds, possess activities for inhibiting adhesion of thrombocytes. ##STR1## Z, A, X, R, R.sup.1 and R.sup.2 are defined in the specification. Some carbostyril derivatives having chemical structural formulas similar to those of carbostyril derivatives and salts thereof represented by the general formula (1a) have been known in prior art references, however the above-mentioned pharmacological activities have not been known to the present date.

  通式（1a）所表示的羧基苯基咪唑衍生物及其盐，包括一些已知化合物，具有抑制血小板粘附活性。其中，Z、A、X、R、R.sup.1和R.sup.2在说明书中有定义。先前的文献中已知一些具有与通式（1a）所表示的羧基苯基咪唑衍生物及其盐相似的化学结构式的羧基苯基咪唑衍生物，但上述药理活性直到现在才被发现。
• Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0240015A2

  公开（公告）日：1987-10-07

  Carbostyril derivatives and salts thereof represented by the general formula (1), including some known compounds, possess activities for inhibiting adhesion of thrombocytes. Some carbostyril derivatives having chemical structural formulas similar to those of carbostyril derivatives and salts thereof represented by the general formula (1) have been known in the prior art references, however above-mentioned pharmacological activities have not been known yet up to the date. Processes for preparing carbostyril derivatives offormu- la (1), a pharmaceutical composition containing them, or a salt thereof, as active ingredient, and their use in the preparation of a medicament for inhibiting adhesion of thrombocytes are also disclosed.

  通式(1)代表的羧基吡啶衍生物及其盐类，包括一些已知化合物，具有抑制血小板粘附的活性。 一些羧基吡啶衍生物的化学结构式与通式(1)代表的羧基吡啶衍生物及其盐类相似，在现有技术参考文献中已为人所知，但上述药理活性至今尚未为人所知。 本发明还公开了制备通式(1)代表的羧基吡啶衍生物、含有它们或其盐类作为活性成分的药物组合物的工艺，以及它们在制备抑制血小板粘附的药物中的用途。
• NISI, TAKAO;UNO, TEHTSUYUKI;KOGA, YASUO;SYU, JOSIO
  作者：NISI, TAKAO、UNO, TEHTSUYUKI、KOGA, YASUO、SYU, JOSIO

  DOI：——

  日期：——
• US5008274A
  申请人：——

  公开号：US5008274A

  公开（公告）日：1991-04-16
• US5434164A
  申请人：——

  公开号：US5434164A

  公开（公告）日：1995-07-18