5,7-dimethoxy-1,4-dimethylquinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,7-dimethoxy-1,4-dimethylquinolin-2-one
• 英文别名: 5,7-Dimethoxy-1,4-dimethylquinolin-2-one
• 化学式: C₁₃H₁₅NO₃
• 分子量: 233.267
• InChiKey: CIMCTKGXYAZOJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  巴豆酸甲酯 、 5,7-dimethoxy-1,4-dimethylquinolin-2-one 在 silver(I) acetate 、 palladium diacetate 、 三甲基丙酮酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以74%的产率得到(E)-methyl 3-(5,7-dimethoxy-1,4-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)but-2-enoate
  参考文献：
  名称：

  两个连续的钯（II）促进的CH烯基化反应，用于合成3-烯基喹诺酮

  摘要：

  AbstractHighly substituted quinolones are obtained through an efficient and atom economical procedure that involves two consecutive palladium(II)‐catalyzed CH alkenylation reactions. A selective 6‐endo intramolecular CH alkenylation leads to 4‐substituted quinolones that have been further functionalized at C‐3 through a second intermolecular CH alkenylation reaction.magnified image

  DOI：

  10.1002/adsc.201400931
• 作为产物：
  描述：

  3,5-dimethoxy-N-methylaniline 在 palladium diacetate 、 溶剂黄146 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 5,7-dimethoxy-1,4-dimethylquinolin-2-one
  参考文献：
  名称：

  两个连续的钯（II）促进的CH烯基化反应，用于合成3-烯基喹诺酮

  摘要：

  AbstractHighly substituted quinolones are obtained through an efficient and atom economical procedure that involves two consecutive palladium(II)‐catalyzed CH alkenylation reactions. A selective 6‐endo intramolecular CH alkenylation leads to 4‐substituted quinolones that have been further functionalized at C‐3 through a second intermolecular CH alkenylation reaction.magnified image

  DOI：

  10.1002/adsc.201400931

文献信息

• Two Consecutive Palladium(II)-Promoted CH Alkenylation Reactions for the Synthesis of 3-Alkenylquinolones
  作者：Verónica Ortiz-de-Elguea、Nuria Sotomayor、Esther Lete

  DOI：10.1002/adsc.201400931

  日期：2015.2.9

  AbstractHighly substituted quinolones are obtained through an efficient and atom economical procedure that involves two consecutive palladium(II)‐catalyzed CH alkenylation reactions. A selective 6‐endo intramolecular CH alkenylation leads to 4‐substituted quinolones that have been further functionalized at C‐3 through a second intermolecular CH alkenylation reaction.magnified image