1-(2-hydroxy-ethyl)-4-methyl-quinolinium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-hydroxy-ethyl)-4-methyl-quinolinium
• 英文别名: 1-(β-Hydroxyaethyl)-4-methyl-chinolinium；2-(4-Methylquinolin-1-ium-1-yl)ethanol
• 化学式: C₁₂H₁₄NO
• 分子量: 188.249
• InChiKey: LILGQFGFIGFPKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  24.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  、 1-(2-hydroxy-ethyl)-4-methyl-quinolinium 、 N,N'-二苯甲脒 在 吡啶 、 乙酸酐 、 sodium perchlorate 作用下， 以 乙二醇甲醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以48%的产率得到
  参考文献：
  名称：

  JP5671525

  摘要：

  公开号：

文献信息

• Imaging Beta-Amyloid Peptides Aggregation
  申请人：Hong Kong Baptist University

  公开号：US20160243264A1

  公开（公告）日：2016-08-25

  The present invention is in the field of pharmaceuticals and chemical industries. In particular, one aspect of the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro and in vivo via magnetic resonance and florescence imaging by using modified carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using the modified carbazole-based fluorophore. The modified carbazole-based fluorophore according to an embodiment of the present invention is prepared by conjugating a carbazole-based fluorophore with magnetic nanoparticles to form a conjugate which is permeable to blood brain barrier of a subject being introduced therewith.

  本发明涉及制药和化工行业。具体而言，本发明的一个方面涉及使用改良的基于咔唑的荧光物质通过磁共振和荧光成像在体内和体外标记、成像和检测β-淀粉样蛋白（Aβ）肽、寡聚体和纤维的方法。本发明的另一个方面涉及一种减少和预防β-淀粉样蛋白在阿尔茨海默病（AD）中聚集的方法，以及使用改良的基于咔唑的荧光物质治疗和/或预防阿尔茨海默病的方法。根据本发明实施例的改良基于咔唑的荧光物质是通过将基于咔唑的荧光物质与磁性纳米颗粒偶联而制备的，形成的共轭物质能够穿透引入的受试者的血脑屏障。
• SWITCHING FLUORESCENT NANOPARTICLE PROBE AND FLUORESCENT PARTICLE IMAGING METHOD USING SAME
  申请人：Hara Isao

  公开号：US20130149252A1

  公开（公告）日：2013-06-13

  The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

  本发明提供一种新型荧光纳米颗粒成像探针，具有切换功能（在纳米颗粒制备过程中熄灭荧光染料，并在成像过程中发射荧光）。一种切换荧光纳米颗粒探针包括：由具有亲水性块链和疏水性块链的两性块聚合物组成的分子组装体；以及封装在分子组装体中的荧光染料，其中（a）亲水性块链包括作为必要亲水性结构单元的一种选自肌氨酸单元和烷氧基单元的单元，（b）疏水性块链包括作为必要疏水性结构单元的一种选自氨基酸单元和羟基酸单元的单元，（c）荧光染料是由式（I）表示的青菁化合物：并且两个或更多分子的荧光染料被封装在单个分子组装体中。
• Class of cyano-substituted asymmetric cyanine dyes, synthesizing method and application thereof
  申请人：DALIAN UNIVERSITY OF TECHNOLOGY

  公开号：US10029996B2

  公开（公告）日：2018-07-24

  The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.

  本发明提供了一类具有以下一般结构式I和其合成方法的氰基取代不对称青光菁染料。本发明中的氰基取代不对称青光菁染料易于合成，具有长的发射波长、高的摩尔消光系数、高的灵敏度、良好的光稳定性、与核酸结合后高的荧光量子产率和低的细胞毒性，有利于作为荧光染料应用，并可用于鉴定核酸分子、临床诊断和免疫测定等领域。
• Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation
  申请人：Hong Kong Baptist University

  公开号：US20140212360A1

  公开（公告）日：2014-07-31

  The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.

  本发明涉及制药和化学工业领域。具体而言，本发明涉及使用基于咔唑的荧光染料对体外β-淀粉样蛋白（Aβ）肽、寡聚体和纤维进行标记、成像和检测的方法。本发明的另一个方面涉及使用基于咔唑的荧光染料减少和预防β-淀粉样肽的聚集，治疗和/或预防阿尔茨海默病（AD）。
• Fluorescent compounds and their use for measuring reticulocytes
  申请人：TOA MEDICAL ELECTRONICS CO., LTD.

  公开号：EP0767382A2

  公开（公告）日：1997-04-09

  A compound represented by the formula (I):    wherein R1 is hydrogen atom or a lower alkyl group; R2 and R3 are independently hydrogen atom, a lower alkyl group or a lower alkoxy groups; R4 is hydrogen atom, an acyl group or a lower alkyl group; R5 is hydrogen atom or an optionally substituted lower alkyl group; Z is sulfur atom, oxygen atom or carbon atom substituted with a lower alkyl group; n is 1 or 2; and X- is an anion.

  由式(I)代表的化合物： 其中 R1 是氢原子或低级烷基；R2 和 R3 分别是氢原子、低级烷基或低级烷氧基；R4 是氢原子、酰基或低级烷基；R5 是氢原子或任选取代的低级烷基；Z 是硫原子、氧原子或被低级烷基取代的碳原子；n 是 1 或 2；X- 是阴离子。