6,7-dimethyl-6H-benzo[h][1,6]naphthyridin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6,7-dimethyl-6H-benzo[h][1,6]naphthyridin-5-one
• 英文别名: 6,7-Dimethylbenzo[h][1,6]naphthyridin-5-one
• 化学式: C₁₄H₁₂N₂O
• 分子量: 224.262
• InChiKey: YJOCFODZOPYFRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘代甲苯 、 2-氯-N-甲基烟酰胺 在 降冰片烯 palladium diacetate 、 三(2-呋喃基)膦 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以55%的产率得到6,7-dimethyl-6H-benzo[h][1,6]naphthyridin-5-one
  参考文献：
  名称：

  Synthesis of 6-Phenanthridinones and Their Heterocyclic Analogues through Palladium-Catalyzed Sequential Aryl−Aryl and N-Aryl Coupling

  摘要：

  6-Phenanthridinones and their heterocyclic analogues were synthesized through a one-pot procedure based on consecutive Pd-catalyzed aryl-aryl and N-aryl coupling from iodoarenes ortho-substituted by electron-releasing substituents and amides of o-bromoarene- and heteroarenecarboxylic acids.

  DOI：

  10.1021/ol0479949

文献信息

• Synthesis of 6-Phenanthridinones and Their Heterocyclic Analogues through Palladium-Catalyzed Sequential Aryl−Aryl and <i>N</i>-Aryl Coupling
  作者：Raffaella Ferraccioli、Davide Carenzi、Ottavio Rombolà、Marta Catellani

  DOI：10.1021/ol0479949

  日期：2004.12.1

  6-Phenanthridinones and their heterocyclic analogues were synthesized through a one-pot procedure based on consecutive Pd-catalyzed aryl-aryl and N-aryl coupling from iodoarenes ortho-substituted by electron-releasing substituents and amides of o-bromoarene- and heteroarenecarboxylic acids.