3-ethyl-5,5-dimethyl-4,5-dihydro-2H-cyclopenta[b]furan-2-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-ethyl-5,5-dimethyl-4,5-dihydro-2H-cyclopenta[b]furan-2-one
• 英文别名: 3-ethyl-5,5-dimethyl-4H-cyclopenta[b]furan-2-one
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: UKOOTIRQWVOIQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3-dimethyloct-5-ynoyl chloride 在 bis(η3-allyl-μ-chloropalladium(II)) dicyclohexylmethylamine 、 三苯基膦 作用下， 以 甲苯 为溶剂， 120.0 ℃ 、101.33 kPa 条件下， 反应 3.0h， 生成 3-ethyl-5,5-dimethyl-4,5-dihydro-2H-cyclopenta[b]furan-2-one
  参考文献：
  名称：

  Palladium-Catalyzed Carbonylation of Yne Esters Leading to γ-Alkylidene α,β-Unsaturated γ-Lactones

  摘要：

  graph The reaction of yne esters with carbon monoxide (1 atm) in the presence of palladium complexes gives bicyclic unsaturated lactone derivatives in good to high yields. The 2-pyridinyloxy group is a good leaving group among leaving groups examined.

  DOI：

  10.1021/ol0514956

文献信息

• Palladium-Catalyzed Carbonylation of Yne Esters Leading to γ-Alkylidene α,β-Unsaturated γ-Lactones
  作者：Yasuyuki Harada、Yoshiya Fukumoto、Naoto Chatani

  DOI：10.1021/ol0514956

  日期：2005.9.1

  graph The reaction of yne esters with carbon monoxide (1 atm) in the presence of palladium complexes gives bicyclic unsaturated lactone derivatives in good to high yields. The 2-pyridinyloxy group is a good leaving group among leaving groups examined.