(2E,4E,6Z)-7-(3,5-di-tert-butyl-2-octyloxyphenyl)-3-methyl-2,4,6-octatrienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2E,4E,6Z)-7-(3,5-di-tert-butyl-2-octyloxyphenyl)-3-methyl-2,4,6-octatrienoic acid
• 英文别名: (2E,4E,6Z)-7-(3,5-ditert-butyl-2-octoxyphenyl)-3-methylocta-2,4,6-trienoic acid
• 化学式: C₃₁H₄₈O₃
• 分子量: 468.72
• InChiKey: NUVXRFXEJGJZIJ-KDHAYTGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.1
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• EXPANSION OF RENEWABLE STEM CELL POPULATIONS
  申请人：Gamida-Cell Ltd.

  公开号：US20160097037A1

  公开（公告）日：2016-04-07

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  离体和体内扩增可再生干细胞的方法，扩增的可再生干细胞群体及其用途。
• Expansion of renewable stem cell populations
  申请人：Peled Tony

  公开号：US20050008624A1

  公开（公告）日：2005-01-13

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  可再生干细胞的离体和体内扩增方法，扩增的可再生干细胞群体及其用途。
• Expansion Of Renewable Stem Cell Populations
  申请人：Peled Tony

  公开号：US20110033427A1

  公开（公告）日：2011-02-10

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  可再生干细胞的离体和体内扩增方法、可再生干细胞扩增群体及其用途。
• Espansion of renewable stem cell populations
  申请人：Gamida Cell Ltd.

  公开号：EP2206773A1

  公开（公告）日：2010-07-14

  The present invention relates to a method of expanding a population of CD34+ hematopoietic stem cells ex-vivo, while at the same time, inhibiting differentiation of the stem cells ex-vivo, the method comprising: (a) culturing said CD34+ hematopoietic stem cells ex-vivo under conditions allowing for cell proliferation, said conditions which comprise providing nutrients, serum and a combination of cytokines including stem cell factor, thrombopoietin, FLt3 ligand, IL-6 and IL-3, and (b) in the same culture medium providing nicotinamide in an amount between 1.0 mM to 10 mM, wherein said cells are cultured for a culture period resulting in expanding the population of CD34+ hematopoietic stem cells while inhibiting differentiation of said CD34+ hematopoietic stem cells ex-vivo to produce an expanded CD34+ hematopoietic stem cell population with an increased proportion of CD34+/Lin- and CD34+/CD38- cells in the expanded culture as compared to CD34+ cells cultured in the presence of cytokines and nutrients without exogenously added nicotinamide.

  本发明涉及一种体内外扩增CD34+造血干细胞群体，同时抑制体内外干细胞分化的方法，该方法包括：(a) 在允许细胞增殖的条件下体内外培养所述 CD34+造血干细胞，所述条件包括提供营养物质、血清和细胞因子组合，包括干细胞因子、血小板生成素、FLt3 配体、IL-6 和 IL-3，以及 (b) 在相同的培养基中提供烟酰胺，其量在 1.0 mM 至 10 mM，其中所述细胞培养一段培养期，导致扩大 CD34+ 造血干细胞群，同时抑制所述 CD34+ 造血干细胞的体外分化，以产生扩大的 CD34+ 造血干细胞群，与在细胞因子和营养物质存在下培养的不外源添加烟酰胺的 CD34+ 细胞相比，扩大的培养物中 CD34+/Lin- 和 CD34+/CD38- 细胞比例增加。
• EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
  申请人：Peled Tony

  公开号：US20050054097A1

  公开（公告）日：2005-03-10

  Ex-vivo methods of expanding hematopoietic stem cells of hematopoietic mononuclear cells that comprise a major fraction of hematopoietic committed cells and a minor fraction of hematopoietic stem and progenitor cells, expanded populations of hematopoietic stem cells obtained thereby and their uses are disclosed.

  本研究公开了由造血干细胞和祖细胞组成的造血单核细胞的体内外造血干细胞扩增方法、由此获得的造血干细胞扩增群及其用途。