Tormentololic acetate ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Tormentololic acetate ester
• 英文别名: tormentic acid；(1R,2R,4aS,6aS,6bR,10R,11R,12aR)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• 化学式: C₃₀H₄₈O₅
• 分子量: 488.708
• InChiKey: OXVUXGFZHDKYLS-PPOXPGKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  35
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Tormentic acid for the treatment of skin disorders
  申请人：China Medical University

  公开号：EP2425832A1

  公开（公告）日：2012-03-07

  Provided is a pharmaceutical composition for at least one selected from the group consisting of inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, inhibiting the phosphorylation of mitogen-activated protein kinase (MAPK), and promoting the expression of collagen, comprising an effective amount of an active component selected from a group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound, and combinations thereof:

  本发明提供了一种药物组合物，用于抑制基质金属蛋白酶（MMP）的活性、抑制基质金属蛋白酶的表达、抑制丝裂原活化蛋白激酶（MAPK）的磷酸化以及促进胶原蛋白的表达，其中包含有效量的活性成分，该活性成分选自由式（I）化合物、该化合物的药学上可接受的盐、该化合物的药学上可接受的酯及其组合组成的组：
• Ursolic acid for inhibiting muscle atrophy
  申请人：University of Iowa Research Foundation

  公开号：EP2571354B1

  公开（公告）日：2020-07-08
• METHODS FOR INHIBITING MUSCLE ATROPHY
  申请人：Adams Christopher M.

  公开号：US20130203712A1

  公开（公告）日：2013-08-08

  In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• COMPOSITIONS AND METHODS FOR INHIBITING MUSCLE ATROPHY AND INDUCING MUSCLE HYPERTROPHY
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US20140371188A1

  公开（公告）日：2014-12-18

  In an aspect, the invention relates to compositions, methods, and kits for inhibiting or preventing skeletal muscle atrophy or inducing muscle hypertrophy by providing to an animal an effective amount of a composition comprising a Gadd45a and/or Cdkn1a inhibitor and an androgen and/or growth hormone elevator or an androgen and/or growth hormone receptor activator. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• PHARMACEUTICAL COMPOSITION AND METHOD FOR REGENERATING MYOFIBERS IN THE TREATMENT OF MUSCLE INJURIES
  申请人：LEAD BILLION LIMITED

  公开号：US20160058797A1

  公开（公告）日：2016-03-03

  A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages or injuries caused by an ischemic disease. The pharmaceutical composition contains an active ingredient compound with a backbone structure of Formula (I). The active ingredient compound is capable of (a) increasing viability of myogenic precursor cells to enable said precursor cells to survive through an absolute ischemic period; (b) reconstituting a damaged blood supply network in said heart region where said injured muscle is located; and (c) enhancing cardiomyogenic differentiation efficiency of said precursor cells down cardiac linage, said steps being performed simultaneously or in any particular order.