[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] (E)-2-methylbut-2-enoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] (E)-2-methylbut-2-enoate
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.5
• InChiKey: ZQSYUKGQHFNSQZ-DFWJVNRMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Acyclic isoprenoid ether derivatives as chemotherapeutics
  申请人：——

  公开号：US20020045584A1

  公开（公告）日：2002-04-18

  A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-linked compound comprises a first acyclic isoprenoid molecule linked via an ether linkage to a second molecule, wherein the second molecule can suppress tumor formation.

  本发明公开了一种抑制患者体内肿瘤细胞生长的方法和组合物。在一个实施方案中，该方法包括用有效量的异戊二烯醚键化合物治疗患者，其中异戊二烯醚键化合物包括通过醚键与第二分子连接的第一无环异戊二烯分子，其中第二分子可抑制肿瘤形成。
• Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics
  申请人：——

  公开号：US20030129683A1

  公开（公告）日：2003-07-10

  This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneously, either directly or following the separation of product from starting material. The invention promotes the discovery of new antibiotics with activity against bacterial transglycosylases by a) laying the groundwork for structural analysis of purified, active transglycosylase (which permits structure-based design); and b) providing an assay that can be used to screen for inhibitors.

  本发明提供了一种直接监测细菌转糖基化酶活性的方法，该方法使用化学酶法合成产生的标记底物，其中标记的选择允许同时检测聚合和非聚合产物，可以直接检测，也可以在产物与起始材料分离后检测。本发明通过 a) 为纯化的活性转糖苷酶的结构分析奠定基础（允许基于结构的设计）；b) 提供可用于筛选抑制剂的检测方法，从而促进发现对细菌转糖苷酶有活性的新抗生素。
• Composition and method for treating cancer
  申请人：——

  公开号：US20040176311A1

  公开（公告）日：2004-09-09

  A composition and an associated method of treating cancer cells by impeding cancer cell growth with the composition are disclosed. The composition includes at least a first and a second HMG-CoA reductase inhibitor, wherein the total amount of the first and second HMG-CoA reductase inhibitors is effective in synergistically impeding cancer cell growth and wherein the cancer cell growth synergistic impedance from the total amount of the first and second HMG-CoA reductase inhibitors is greater than a theoretical additive effect from the combined first and second HMG-CoA reductase inhibitors. The present composition does not simultaneously contain both a tocotrienol and an ionone when the composition contains only a first and a second HMG-CoA reductase inhibitor. The method includes treating cancer cells with the claimed composition to impede cancer cell growth.

  本发明公开了一种通过使用该组合物抑制癌细胞生长来治疗癌细胞的组合物和相关方法。该组合物至少包括第一种和第二种HMG-CoA还原酶抑制剂，其中第一种和第二种HMG-CoA还原酶抑制剂的总量能有效地协同阻碍癌细胞生长，并且第一种和第二种HMG-CoA还原酶抑制剂总量产生的癌细胞生长协同阻碍作用大于第一种和第二种HMG-CoA还原酶抑制剂组合产生的理论相加作用。当组合物仅含有第一和第二种 HMG-CoA 还原酶抑制剂时，本组合物不会同时含有生育三烯酚和离子酮。该方法包括用所述组合物治疗癌细胞，以阻碍癌细胞生长。
• MONOTERPENOID DERIVATIVES FOR TREATMENT OF CANCER
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：EP1061907A1

  公开（公告）日：2000-12-27
• BACTERIAL TRANSGLYCOSYLASES: ASSAYS FOR MONITORING THE ACTIVITY USING LIPID II SUBSTRATE ANALOGS AND METHODS FOR DISCOVERING NEW ANTIBIOTICS
  申请人：PRINCETON UNIVERSITY

  公开号：EP1159293A1

  公开（公告）日：2001-12-05