双酚沙丁醋酸酯 | 14008-48-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双酚沙丁醋酸酯
• 英文名称: bisoxatin diacetate
• 英文别名: 2,2-Bis-(p-acetoxyphenyl)-3-oxodihydro-1,4-benzoxazin；2,2-bis(4-acetoxyphenyl)-2H-1,4-benzoxazin-3(4H)-one；bisoxatin acetate；[4-[2-(4-acetyloxyphenyl)-3-oxo-4H-1,4-benzoxazin-2-yl]phenyl] acetate
• CAS: 14008-48-1
• 化学式: C₂₄H₁₉NO₆
• 分子量: 417.418
• InChiKey: ZCBJDQBSLZREAA-UHFFFAOYSA-N

物化性质

• 熔点：
  190°
• 沸点：
  604.4±55.0 °C(Predicted)
• 密度：
  1.296±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

文献信息

• [EN] PROTEASOME ACTIVITY ENHANCING COMPOUNDS<br/>[FR] COMPOSÉS RENFORÇANT L'ACTIVITÉ DES PROTÉASOMES
  申请人：PROTEOSTASIS THERAPEUTICS INC

  公开号：WO2015073528A1

  公开（公告）日：2015-05-21

  The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, the methods of synthesis of the compouds of interest, and to methods for the treatment of a condition associated with a dysfunction in proteostasis, such as cancer, inflammatory conditions, neurodegeneration, metabolic conditions, comprising administering an effective amount of a compound of the invention.

  本发明涉及具有化学式（I）、（II）、（III）、（IV）和（V）的化合物，其组成物，所述化合物的合成方法，以及用于治疗与蛋白质稳态功能障碍相关的疾病的方法，例如癌症、炎症性疾病、神经退行性疾病、代谢性疾病，包括给予本发明化合物的有效量。
• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Multifunctional materials consisting of regioregular poly(3-alkylthiophene)s covalently attached on carbon nanotubes for photovoltaic applications
  申请人：Chochos Christos

  公开号：US20110082261A1

  公开（公告）日：2011-04-07

  Facile ways towards the integration of the regioregular poly(3-alkylthiophene)s onto carbon nanotubes, providing multifunctional materials that combine the extraordinary properties of the carbon nanotubes with those of regioregular poly(3-alkylthiophene)s, are presented.

  本文介绍了将regioregular聚(3-烷基噻吩)轻松地集成到碳纳米管上的方法，从而提供了将碳纳米管的非凡特性与regioregular聚(3-烷基噻吩)的特性相结合的多功能材料。
• [EN] SMALL MOLECULE ADAPTER REGULATED<br/>[FR] ADAPTATEUR DE PETITE MOLÉCULE RÉGULÉ
  申请人：UNIV YALE

  公开号：WO2019010201A1

  公开（公告）日：2019-01-10

  In one embodiment, the invention' provides a chimeric antigen receptor (CAR) T cell which is conjugated to a bi-functional molecule which is specific for both an extracellular binding domain of the chimeric antigen receptor (CAR) T cell and prostate-specific membrane antigen (PSMA). The chimeric antigen receptor (CAR) T cell contains a T cell signaling domain and the extracellular binding domain of the chimeric antigen receptor (CAR) T cell is not specific for prostate-specific membrane antigen (PSMA). Compositions and methods of treatment using these CAR T cells are also disclosed.

  在一种实施例中，本发明提供了一种嵌合抗原受体（CAR）T细胞，该细胞与一种双功能分子结合，该分子既特异性结合嵌合抗原受体（CAR）T细胞的细胞外结合域，也特异性结合前列腺特异性膜抗原（PSMA）。该嵌合抗原受体（CAR）T细胞含有T细胞信号传导结构域，而嵌合抗原受体（CAR）T细胞的细胞外结合域并非特异性结合前列腺特异性膜抗原（PSMA）。本发明还公开了使用这些CAR T细胞的组合物和治疗方法。
• [EN] SMALL MOLECULES BASED FREE-STANDING FILMS AND HYBRID MATERIALS<br/>[FR] FILMS AUTONOMES À BASE DE PETITES MOLÉCULES ET MATÉRIAUX HYBRIDES
  申请人：YEDA RES & DEV

  公开号：WO2018229765A1

  公开（公告）日：2018-12-20

  This invention is directed to an aromatic material based free-standing film, a hybrid of organic crystalline materials and inorganic carbon nanomaterials, process of preparation and uses thereof. The film, which comprises a fibrous organic nanocrystals of an aromatic material, is mechanically and thermally stable. This film is optionally reinforced by hybridization with a reinforcement material, such as carbon nanotube, carbon material, a polysaccharide, a nanoclay a metal, metal alloy, or an organic polymer. The hybrid film of organic nanocrystals and carbon nanotubes (ONC/CNT) has high conductivity and high thermal stability. The films or hybrids of this invention are used as microfiltration membranes for various materials, in electrodes or perovskite solar cells.

  本发明涉及一种基于芳香材料的自立薄膜，是有机晶体材料和无机碳纳米材料的混合物，以及其制备方法和用途。该薄膜包含芳香材料的纤维状有机纳米晶体，具有机械和热稳定性。该薄膜可以通过与增强材料混合来加固，例如碳纳米管、碳材料、多糖、纳米粘土、金属、金属合金或有机聚合物。有机纳米晶体和碳纳米管（ONC/CNT）的混合薄膜具有高导电性和高热稳定性。本发明的薄膜或混合物可用作各种材料的微过滤膜，在电极或钙钛矿太阳能电池中使用。