6-[3-(1-Adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid;benzene-1,4-diol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 6-[3-(1-Adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid;benzene-1,4-diol
• 化学式: C34H34O5
• 分子量: 522.6
• InChiKey: HVIPACPOBUFDFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.78
• 重原子数：
  39
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Skin depigmenting compositions comprising adapalene and at least one depigmenting active agent
  申请人：Pelisson Isabelle

  公开号：US20050163731A1

  公开（公告）日：2005-07-28

  Topically applicable skin depigmenting compositions, suited for treatment of such hyperpigmentary disorders as melasma and chloasma, contain a thus effective amount of at least one skin depigmenting active agent, for example hydroquinone or 4-hydroxyanisole, in admixture with a depigmentation-accelerating amount of adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-napthanoic acid), and optionally with at least one sunscreen, formulated into a topically applicable, physiologically acceptable medium therefor.

  适用于治疗黄褐斑和黄褐斑等色素沉着性疾病的局部皮肤褪色组合物含有至少一种有效量的皮肤褪色活性剂，例如对苯二酚或 4-羟基苯甲醚、与一定量的阿达帕林（6-[3-(1-金刚烷基)-4-甲氧基苯基]-2-萘酸）和至少一种防晒剂混合，配制成局部适用的生理上可接受的介质。
• Skin depigmenting compositions comprising adapalene, at least one depigmenting agent and at least one anti-inflammatory agent
  申请人：Pelisson Isabelle

  公开号：US20080219936A1

  公开（公告）日：2008-09-11

  Depigmenting compositions for the skin, comprise, formulated into a physiologically acceptable medium, adapalene, at least one depigmenting agent and at least one anti-inflammatory agent, and to the pharmaceutical/cosmetic applications thereof.