(1E)-1-(3,3-diethyl-5,5-dimethylcyclohexylidene)propan-2-amine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1E)-1-(3,3-diethyl-5,5-dimethylcyclohexylidene)propan-2-amine
• 化学式: C₁₅H₂₉N
• 分子量: 223.4
• InChiKey: PQQBYKLJMVSXAC-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• UNSATURATED 1-AMINO-ALKYLCYCLOHEXANE NMDA, 5HT3 AND NEURONAL NICOTINIC RECEPTOR ANTAGONISTS
  申请人：Merz Pharma GmbH & Co. KGaA

  公开号：EP1442008A1

  公开（公告）日：2004-08-04
• US6828462B2
  申请人：——

  公开号：US6828462B2

  公开（公告）日：2004-12-07
• [EN] UNSATURATED 1-AMINO-ALKYLCYCLOHEXANE NMDA, 5HT3 AND NEURONAL NICOTINIC RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES 1-AMINO-ALKYLCYCLOHEXANE INSATURES DES RECEPTEURS DE NMDA, DES RECEPTEURS 5HT3 ET DES RECEPTEURS NICOTINIQUES NEURONAUX
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2003040084A1

  公开（公告）日：2003-05-15

  Unsaturated 1-amino-alkylcyclohexane compounds which are systemically-active as NMDA, 5HT3 and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
• [EN] COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS<br/>[FR] THERAPIE COMBINEE FAISANT APPEL A DES DERIVES DE 1-AMINOCYCLOHEXANE AINSI QU'A DES INHIBITEURS D'ACETYLCHOLINESTERASE
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2004037234A2

  公开（公告）日：2004-05-06

  A drug combination therapy useful in the treatment of dementia associated with disorders of the central nervous system, e.g. to delay the onset or progression of Alzheimer’s disease, cerebrovascular disease or Down’s syndrome, comprises a combination of a 1-aminocyclohexane derivative such as memantine or neramexane and an acetylcholinesterase inhibitor such as galantamine, tacrine, donepezil or rivastigmine.