11H-indeno[1,2-c]quinolin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 11H-indeno[1,2-c]quinolin-11-one
• 英文别名: indeno[1,2-c]quinolin-11-one
• 化学式: C₁₆H₉NO
• 分子量: 231.254
• InChiKey: MAZBIMWZPZXULP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  11H-indeno[1,2-c]quinolin-11-one 在 一水合肼 作用下， 生成 11H-indeno[1,2-c]quinoline
  参考文献：
  名称：

  Borsche, Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 127,134

  摘要：

  DOI：
• 作为产物：
  描述：

  苯丙酮酸 在 sodium hydroxide 、 氯化亚砜 作用下， 生成 11H-indeno[1,2-c]quinolin-11-one
  参考文献：
  名称：

  Borsche, Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 127,134

  摘要：

  DOI：

文献信息

• NOVEL INDENO[1,2-c]QUINOLIN-11-ONE DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF
  申请人：National Defense Medical Center

  公开号：US20150197492A1

  公开（公告）日：2015-07-16

  The present invention provides a novel series of indeno[1,2-c]quinolin-11-one derivatives and further provides their preparation methods as well as applications. Said applications includes utilizing such derivatives as pharmaceutical compositions for treating cancers; moreover, said applications includes the capability possessed by such derivatives to effectively inhibit cancer cell growth as well as the activity of Type I topoisomerases and can be further applied for cancer treatment.

  本发明提供了一系列新颖的indeno[1,2-c]quinolin-11-one衍生物，并进一步提供其制备方法以及应用。所述应用包括将这些衍生物用作治疗癌症的药物组合物；此外，所述应用包括这些衍生物具有有效抑制癌细胞生长以及抑制Ⅰ型拓扑异构酶活性的能力，并可进一步应用于癌症治疗。
• Access to Benzo[<i>a</i>]carbazoles and Indeno[1,2-<i>c</i>]quinolines by a Gold(I)-Catalyzed Tunable Domino Cyclization of Difunctional 1,2-Diphenylethynes
  作者：Xiaoshi Peng、Lifeng Zhu、Yuqian Hou、Yadong Pang、Yangming Li、Jiayue Fu、Lu Yang、Bin Lin、Yongxiang Liu、Maosheng Cheng

  DOI：10.1021/acs.orglett.7b01358

  日期：2017.7.7

  The cyclization order of the difunctional 1,2-diphenylethynes was precisely tuned under the catalysis of gold by changing the nitrogen substitution of the substrates, leading to the facile preparation of benzo[a]carbazole and indeno[1,2-c]quinoline derivatives. The mechanisms of these domino cyclizations were probed by control experiments, and an insight into the selectivity of the cyclization was

  通过改变底物的氮取代，在金的催化下精确调节了双官能1,2-二苯乙炔的环化顺序，从而轻松制备了苯并[ a ]咔唑和茚并[1,2- c ]喹啉衍生物。通过控制实验探索了这些多米诺环化的机理，并通过密度泛函理论（DFT）计算获得了对环化选择性的深入了解。这项研究代表了访问苯并[ a ]咔唑和茚并[1,2- c ]喹啉的统一而通用的方法。
• Intramolecular Acylation of Unactivated Pyridines or Arenes via Multiple C–H Functionalizations: Synthesis of All Four Azafluorenones and Fluorenones
  作者：Joydev K. Laha、Krupal P. Jethava、Sagarkumar Patel、Ketul V. Patel

  DOI：10.1021/acs.joc.6b02065

  日期：2017.1.6

  unactivated pyridines via multiple C(sp3/sp2)–H functionalizations of a methyl, hydroxymethyl, or aldehyde group has been developed providing a general access to all four azafluorenones. The application of this protocol is further demonstrated to the synthesis of azafluorenone related fused nitrogen heterocycles and fluorenones. In addition, design and synthesis of a novel fluorene based organic emitter for

  通过甲基，羟甲基或醛基团的多个C（sp 3 / sp 2）–H官能化作用，未活化的吡啶进行了前所未有的分子内酰化反应，从而提供了对所有四个氮杂氟烯酮的通用途径。该方案的应用进一步证明了与氮杂芴酮相关的稠合氮杂环和芴酮的合成。另外，还报道了潜在用于有机发光器件（OLED）的新型芴基有机发射体的设计和合成。
• Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same
  申请人：Tzeng Cherng-Chyi

  公开号：US20090111987A1

  公开（公告）日：2009-04-30

  Disclosed herein are novel imino-indeno[1,2-c]quinoline derivatives of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these derivatives, their synthetic precursors and their uses in the manufacture of pharmaceutical compositions for use in the treatment of cancers.

  本文披露了新型的imino-indeno[1,2-c]quinoline 衍生物，其化学式为(I)，或其药学上可接受的盐或溶剂，其中每个取代基的定义如本说明书和权利要求中所述。此外，还披露了这些衍生物的制备过程、它们的合成前体以及它们在制造用于治疗癌症的药物组合物中的用途。
• Borsche; Sinn, Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 146,152
  作者：Borsche、Sinn

  DOI：——

  日期：——