2-(tert-butyl)cyclohexanecarbonitrile

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(tert-butyl)cyclohexanecarbonitrile
• 英文别名: 2-Tert-butylcyclohexane-1-carbonitrile
• 化学式: C₁₁H₁₉N
• 分子量: 165.279
• InChiKey: XIRYSMCDNSGPCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (5R,6E,8E,10E,13S,14S,15R,16Z)-15-羟基-5-甲氧基-14,16-二甲基-3,22,24-三羰基-2-氮杂二环[18.3.1]二十四碳-1(23),6,8,10,16,20-六烯-13-基N-(环己基羰基)-D-丙氨酸酸酯 、 碘代叔丁烷 在 copper(l) iodide 、 水 、 锌 作用下， 以27%的产率得到2-(tert-butyl)cyclohexanecarbonitrile
  参考文献：
  名称：

  Alkenenitriles:  Conjugate Additions of Alkyl Iodides with a Silica-Supported Zinc−Copper Matrix in Water

  摘要：

  A new silica-supported zinc-copper matrix reagent promotes the conjugate addition of alkyl iodides to cyclic and acyclic alkenenitriles in water. X-ray diffraction and electron microscopy techniques suggest that the active copper species generated from elemental zinc and copper(I) iodide is finely dispersed, zerovalent copper. Alkyl iodides react with the silica-supported reagent to generate putative radicaloid intermediates that efficiently add to alkenenitriles to provide beta-substituted nitriles. Conjugate additions to acyclic and cyclic 5-7-membered alkenenitriles are most effective for primary alkyliodides, although secondary and tertiary alkyliodides are viable reaction partners. The strategy addresses the challenge of performing conjugate additions to disubstituted alkenenitriles and demonstrates the beneficial role of the silica-supported reagent.

  DOI：

  10.1021/jo0711539

文献信息

• ALPHA-SUBSTITUTED CYCLOPENTANECARBONITRILES OR CYCLOHEXANECARBONITRILES AND THEIR USE IN PERFUMERY
  申请人：Gaudin Jean-Marc

  公开号：US20100247467A1

  公开（公告）日：2010-09-30

  The present invention relates to the field of perfumery. More particularly, it concerns α-substituted cyclopentanecarbonitriles or cyclohexanecarbonitriles. These compounds are valuable perfuming ingredients having fruity or jasminic odor notes. The present invention also concerns the compositions or articles containing the compound.

  本发明涉及香料领域。更具体地，涉及α-取代的环戊烷基腈或环己烷基腈。这些化合物是有价值的香料成分，具有果香或茉莉香气。本发明还涉及含有该化合物的组合物或物品。
• Method for the preparation of cross-linked polyethylene foams and foams produced by the method
  申请人：BP CHEMICALS FOAMS BUSINESS, SA

  公开号：EP0210760A2

  公开（公告）日：1987-02-04

  A foam of cross-linked polyethylene having micnocell strucutre is prepared using a chemical cross-linking initiator having a 10 hours half life temperature of from 80°C to 110°C. In a proferred embodiment, the chemical cross-linking agent is employed in combination with co-cross-linking agent such as triallyl cyanurate.

  使用化学交联引发剂制备具有微孔结构的交联聚乙烯泡沫，化学交联引发剂的半衰期为 10 小时，温度为 80°C 至 110°C。在一个推荐的实施方案中，化学交联剂与共交联剂（如氰尿酸三烯丙酯）结合使用。
• Resorcinol derivatives
  申请人：Sutter West Bay Hospitals

  公开号：US10202322B2

  公开（公告）日：2019-02-12

  The disclosure relates to cannabinoid derivative compounds, pharmaceutical compositions made thereof, and methods for treating various diseases and disorders including cancer.

  本公开涉及大麻素衍生物化合物、由其制成的药物组合物以及治疗包括癌症在内的各种疾病和失调的方法。
• Alpha-substituted cyclopentanecarbonitriles or cyclohexanecarbonitriles and their use in perfumery
  申请人：Firmenich S.A.

  公开号：EP2217563B1

  公开（公告）日：2013-01-30
• CANNABIDINOID DERIVATIVES
  申请人：SUTTER WEST BAY HOSPITALS

  公开号：US20130209483A1

  公开（公告）日：2013-08-15

  The disclosure relates to cannabinoid derivative compounds, pharmaceutical compositions made thereof, and methods for treating various diseases and disorders including cancer.