(Z)-pentacos-16-en-8-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-pentacos-16-en-8-one
• 化学式: C₂₅H₄₈O
• 分子量: 364.656
• InChiKey: NMNUYAZIRHQMER-YPKPFQOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (Z)-pentacos-16-en-8-one 以 乙醇 、 甲苯 为溶剂， 反应 32.0h， 生成 (Z)-2-(methyl(pentacos-16-en-8-yl)amino)ethane-1-thiol
  参考文献：
  名称：

  [EN] IONIZABLE LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF
  [FR] LIPIDES IONISABLES ET COMPOSITIONS DE NANOPARTICULES ASSOCIÉES

  摘要：

  公开号：

  WO2021102411A8
• 作为产物：
  描述：

  油酸 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 2.25h， 生成 (Z)-pentacos-16-en-8-one
  参考文献：
  名称：

  [EN] IONIZABLE LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF
  [FR] LIPIDES IONISABLES ET COMPOSITIONS DE NANOPARTICULES ASSOCIÉES

  摘要：

  公开号：

  WO2021102411A8

文献信息

• PROCESS FOR PRODUCING COMPOUND WITH ANTI-HCV POTENCY AND INTERMEDIATE FOR USE THEREIN
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1857456A1

  公开（公告）日：2007-11-21

  A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. A compound represented by the formula (1-8): [wherein Y represents a group represented by the following formula: Q represents a protected carbonyl group; D represents -(CH2)m-R', etc.; and n represents an integer of 0 to 10].

  本发明提供了一种方法，通过使用具有特定手性助剂的化合物作为起始化合物，可以在少量步骤内选择性地高产率合成具有 HCV 复制抑制活性和所需光学活性的化合物。 由式（1-8）代表的化合物： [其中 Y 代表下式所表示的基团： Q 代表受保护的羰基；D 代表-(CH2)m-R'等；n 代表 0 至 10 的整数]。
• EP1857456
  申请人：——

  公开号：——

  公开（公告）日：——
• Production Process of Compound Having Anti-Hcv Action and Intermediate Thereof
  申请人：Kato Tatsuya

  公开号：US20080293950A1

  公开（公告）日：2008-11-27

  A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. A compound represented by the formula (1-8): [wherein Y represents a group represented by the following formula: Q represents a protected carbonyl group; D represents —(CH 2 ) m —R′, etc.; and n represents an integer of 0 to 10].
• Intermediate compound for synthesis of viridiofungin a derivative
  申请人：Kato Tatsuya

  公开号：US20100152456A1

  公开（公告）日：2010-06-17

  A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. A compound represented by the formula (1-8): wherein Y represents a group represented by the following formula: Q represents a protected carbonyl group; D represents —(CH 2 ) m —R′, etc.; and n represents an integer of 0 to 10.
• US7897783B2
  申请人：——

  公开号：US7897783B2

  公开（公告）日：2011-03-01