吡啶,2-[4-(氯甲基)苯氧基]- | 194017-71-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 吡啶,2-[4-(氯甲基)苯氧基]-
• 英文名称: 2-[4-(chloromethyl)phenoxy]pyridine
• 英文别名: (4-(2-pyridyloxy)phenyl)methyl chloride；4-(pyrid-2-yloxy)benzyl chloride
• CAS: 194017-71-5
• 化学式: C₁₂H₁₀ClNO
• 分子量: 219.671
• InChiKey: UQQYLHCQWCGNKP-UHFFFAOYSA-N

物化性质

• 沸点：
  339.4±27.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氨基-6-甲基-3-吡啶羧酸 、 吡啶,2-[4-(氯甲基)苯氧基]- 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以91%的产率得到2-amino-6-methyl nicotinic acid-4-(2-pyridyloxy)benzyl
  参考文献：
  名称：

  METHOD OF PRODUCING 2-AMINONICOTINIC ACID BENZYL ESTER DERIVATIVES

  摘要：

  本发明提供了一种高产率和高纯度生产2-氨基烟酸苄酯衍生物的方法。通过在极性溶剂中，在规定碱的存在下，将苄卤代衍生物与2-氨基烟酸衍生物反应，可以获得高产率和高纯度的2-氨基烟酸苄酯衍生物。

  公开号：

  US20160318868A1
• 作为产物：
  描述：

  [4-(2-吡啶基氧基)苯基]甲醇 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 吡啶,2-[4-(氯甲基)苯氧基]-
  参考文献：
  名称：

  METHOD OF PRODUCING 2-AMINONICOTINIC ACID BENZYL ESTER DERIVATIVES

  摘要：

  本发明提供了一种高产率和高纯度生产2-氨基烟酸苄酯衍生物的方法。通过在极性溶剂中，在规定碱的存在下，将苄卤代衍生物与2-氨基烟酸衍生物反应，可以获得高产率和高纯度的2-氨基烟酸苄酯衍生物。

  公开号：

  US20160318868A1

文献信息

• [EN] N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES<br/>[FR] N-(ARYLMETHYL SUBSTITUE)-4-(METHYL DISUBSTITUE) PIPERIDINES ET PYRIDINES ASSOCIEES
  申请人：FMC CORP

  公开号：WO2004060371A1

  公开（公告）日：2004-07-22

  It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected fronn 0 or 1 ; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现在已经发现，某些新型的N-(取代芳基)-4(二取代甲基)哌啶和吡啶衍生物具有意想不到的杀虫活性。这些化合物由公式(I)表示：其中m、n、q、r和s分别独立地从0或1中选择；p为0、1、2或3；A为C或CH；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此处均有完整描述。此外，还披露了包含公式I中至少一种化合物的杀虫有效量的组合物，以及可选地含有至少一种第二化合物的有效量，其中至少一种杀虫兼容载体；以及控制昆虫的方法，包括将上述组合物应用于昆虫存在或预计存在的地点。
• N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines
  申请人：Ding Ping

  公开号：US20060135504A1

  公开（公告）日：2006-06-22

  It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现已发现某些新型N-(取代芳基)-4(二取代甲基)哌啶和吡啶衍生物具有出乎意料的杀虫活性。这些化合物由式(I)表示：其中m、n、q、r和s独立地选自0或1；p为0、1、2或3；A为C或CH；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此完整描述。此外，还公开了包含式(I)中至少一种化合物的杀虫有效量和可选的第二种化合物的有效量，以及至少一种杀虫兼容载体的组合物；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。
• N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
  申请人：Ding Ping

  公开号：US20060166962A1

  公开（公告）日：2006-07-27

  It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is CH or N; and B, D, E, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现在已经发现某些新型N-（取代芳基）-4-（二取代甲基）哌啶和吡啶衍生物具有意外的杀虫活性。这些化合物由公式（I）表示：其中m、n、q、r和s独立地选自0或1；p为0、1、2或3；A为CH或N；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此完全描述。此外，还披露了包含公式I中至少一种化合物的杀虫有效量的组合物，以及可选地，至少一种第二化合物的有效量，具有至少一种杀虫兼容载体；以及用于控制昆虫的方法，包括将所述组合物施用到昆虫存在或预计存在的地点。
• N-Substituted Azacycles
  申请人：Theodoridis George

  公开号：US20090215821A1

  公开（公告）日：2009-08-27

  N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  式（I）所代表的N-取代的杂环衍生物化合物：其中m、q、r、t和u独立地选择0或1；p为0、1、2或3；A、B、D、X、Y、R、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11在此完全描述。该化合物在包含式I至少一种化合物的杀虫有效量和杀虫相容载体的组合物中特别有用；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的场所。
• NOVEL THIOL DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1132379A1

  公开（公告）日：2001-09-12

  The present invention provides a compound represented by Formula: wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and the like, each R1 may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group, an optionally substituted heterocyclic group or SR2, etc., X1 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group or -NR3-, etc, X2 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group, -NR4-, -O- or -S(O)p-(wherein p is 0, 1 or 2), each Y may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, a halogen atom, a carboxyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, SR5, an oxo group, a thioxo group, an optionally substituted imino group, a nitro group, a cyano group, etc., each m may be same or different and is 0 or 1, n is an integer of 1 to 3, q1 is an integer of 1 to 2n+4, q2 is an integer of 0 to 2n+3, and the sum of q1 and q2 is 2n+4 or a salt thereof.

  本发明提供了一种由式表示的化合物： 其中，环 A 和环 B 可以相同或不同，并且各自是任选取代的同环或杂环等，每个 R1 可以相同或不同，并且是氢原子、任选取代的烃基、酰基、任选取代的杂环基团或 SR2 等、X1 是键、任选取代的二价 C1-3 脂肪族烃基或-NR3-等，X2 是键、任选取代的二价 C1-3 脂肪族烃基、-NR4-、-O-或-S(O)p-（其中 p 为 0、1 或 2），每个 Y 可以相同或不同，并且是氢原子、任选取代的烃基、卤素原子、羧基、酰基、任选取代的羟基、任选取代的氨基、SR5、氧代基团、硫代基团、任选取代的亚氨基、硝基、氰基等。,每个 m 可以相同或不同，且为 0 或 1，n 为 1 至 3 的整数，q1 为 1 至 2n+4 的整数，q2 为 0 至 2n+3 的整数，且 q1 和 q2 之和为 2n+4 或其盐。