咪多卡 | 27885-92-3

• 物质功能分类: 原料药 - 抗寄生虫病药 - 抗原虫药
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 咪多卡
• 中文别名: 双咪苯脲；咪唑苯脲；N,N'-二(3-(4,5-二氢-1H-咪唑-2-基)苯基)脲；3,3’-双(α-咪唑啉-α-基)均二苯脲；N,N"-二(3-(4,5-二氢-1H-咪唑-2-基)苯基)脲；咪多卡双咪唑林苯基脲咪唑苯脲
• 英文名称: imidocarb
• 英文别名: 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea
• CAS: 27885-92-3
• 化学式: C₁₉H₂₀N₆O
• mdl: MFCD00693581
• 分子量: 348.407
• InChiKey: SCEVFJUWLLRELN-UHFFFAOYSA-N

物化性质

• 熔点：
  >235°C (dec.)
• 密度：
  1.39±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  89.9
• 氢给体数：
  4
• 氢受体数：
  3

安全信息

• 储存条件：
  室温

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Imidocarb
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Imidocarb
CAS number: 27885-92-3

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C19H20N6O
Molecular weight: 348.4

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

概述

双咪苯脲是一种兼具预防和治疗作用的新型抗梨形虫药。它不仅能有效治疗巴贝斯虫病和泰勒虫病，还能提供较好的预防效果。该药物可以直接作用于巴贝斯虫体，改变其细胞核的数量和大小，并使细胞质产生空泡现象。与其他药物相比，双咪苯脲对巴贝斯虫的疗效更优。

应用

双咪苯脲是一种兽药用化学品，属于抗梨形虫药物二苯脲类联脒衍生物，具有重要的生物活性。它具有广谱、低毒、应用范围广、作用时间长和用药剂量小等优点，不仅对家畜梨形虫病、无浆体病及猪犬的附红细胞体病有很好的治疗效果，也具有良好的预防效果。

化学性质

双咪苯脲为固体。熔点为350℃（分解）。

用途

该药物是一种高效的抗焦虫病药，毒性低且用药剂量小。对于严重感染的牛和羊巴贝西焦虫病，使用咪唑脲治疗可以迅速控制病情，并在三个月后未见复发现象。此外，它还具有预防焦虫病的作用。

生产方法

双咪苯脲可通过将间硝基苯甲酸乙酯在三甲基铝存在下与乙二胺反应制得2-（3-硝基苯）咪唑啉，收率为90%；然后还原成2-（3-氨基苯）咪唑啉，最后经光气化和缩合得到最终产品。

反应信息

• 作为反应物：
  描述：

  咪多卡 在 水 、 potassium hydroxide 作用下， 以 乙腈 为溶剂， 以3 g的产率得到1-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3-[3-(2-hydroxyimidazolidin-2-yl)phenyl]urea
  参考文献：
  名称：

  一种二丙酸咪唑苯脲杂质A及其杂质A制备方法

  摘要：

  本发明涉及一种二丙酸咪唑苯脲杂质A及其杂质A制备方法，杂质A结构式如下式Ⅰ所示：本发明的二丙酸咪唑苯脲杂质A对二丙酸咪唑苯脲质量的提高，以及从源头上控制二丙酸咪唑苯脲的安全性具有重要的现实意义；可用于二丙酸咪唑苯脲原料药和制剂的注册、质量研究、工艺研究、杂质制备和作为杂质对照品，对制定和提高二丙酸咪唑苯脲的质量标准提供有效的数据支持，为二丙酸咪唑苯脲的临床安全使用提供有效保障。

  公开号：

  CN110256354A
• 作为产物：
  描述：

  3-硝基苯甲酸甲酯 在 盐酸 、 sulfur 、 sodium hydroxide 、 锌 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 11.0h， 生成 咪多卡
  参考文献：
  名称：

  一种咪唑苯脲的制备方法

  摘要：

  本发明公开了一种咪唑苯脲的制备方法，包括以下步骤：将间硝基咪唑啉、三氯化铁和活性炭溶于正丁醇中，升温滴加80wt％水合肼，反应结束后，75‑80℃过滤，滤液降温，慢慢析出固体，过滤得到间氨基咪唑啉；将间氨基咪唑啉与N,N'‑羰基二咪唑、二异丙基乙胺溶于DMF中，升温，慢慢析出固体，降温，过滤，得到咪唑苯脲。间硝基咪唑啉的制备方法为：将间硝基苯甲醛、乙二胺、三甲基氯硅烷溶于DMF中，在氮气保护下升温，反应完毕后降至室温，加水慢慢析出固体，过滤后得到。本发明避免了过量使用原料产生副反应的问题，同时制备方法成本低、收率高、毒性低、所用试剂廉价易得、溶剂能够回收利用、适合工业化生产。

  公开号：

  CN114671810A

文献信息

• ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF
  申请人：Meng Charles Q.

  公开号：US20140142114A1

  公开（公告）日：2014-05-22

  The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 and X 8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

  本发明涉及以下式（I）的新型驱虫化合物： 其中 Y和Z分别是双环碳环或双环杂环基团，或者Y或Z中的一个是双环碳环或双环杂环基团，另一个是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，以及变量X 1 ，X 2 ，X 3 ，X 4 ，X 5 ，X 6 ，X 7 和X 8 如本文所定义。本发明还提供了包含本发明的驱虫化合物的兽药组合物，以及它们用于治疗和预防动物寄生虫感染的用途。
• [EN] ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS<br/>[FR] COMPOSÉS DEPSIPEPTIDIQUES ANTHELMINTHIQUES
  申请人：MERIAL INC

  公开号：WO2018093920A1

  公开（公告）日：2018-05-24

  The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

  本发明提供了公式（I）的环状脱氨肽化合物，其中至少一个碳原子的立体化学构型与自然存在的环状脱氨肽PF1022A的基团Cy1、Cy2、R1、R2、R3、R4、Ra和Rb相比发生了倒置。该发明还提供了包含这些化合物的组合物，对危害动物的寄生虫具有有效性。这些化合物和组合物可用于对抗哺乳动物和鸟类体内或体表的寄生虫。该发明还提供了一种改进的方法，用于根除、控制和预防鸟类和哺乳动物的寄生虫感染。
• FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES
  申请人：Bayer Aktiengesellschaft

  公开号：US20200383334A1

  公开（公告）日：2020-12-10

  The invention relates to novel compounds of the formula (I) in which Aa, Ab, Ac, Ad, Q, R 1 and n have the definitions given above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.

  这项发明涉及公式（I）的新化合物， 其中Aa、Ab、Ac、Ad、Q、R1和n具有上述给定的定义， 以及它们作为杀螨剂和/或杀虫剂用于控制动物害虫的用途，以及用于它们制备的工艺和中间体。
• [EN] ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME<br/>[FR] DIHYDROAZOLES ANTIPARASITAIRES ET COMPOSITIONS LES INCLUANT
  申请人：MERIAL LTD

  公开号：WO2011075591A1

  公开（公告）日：2011-06-23

  The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

  本发明涉及式(I)的新型二氢咪唑及其盐：其中R1、A1、A2、G、X和Y如描述中所定义，以及它们的组合物、制备方法以及它们用于预防或治疗动物寄生虫感染或寄生虫侵袭以及作为杀虫剂的用途。
• SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS
  申请人：Bayer Aktiengesellschaft

  公开号：US20190269134A1

  公开（公告）日：2019-09-05

  The present invention relates to the use of a compound of the general formula (I) in which M and D have the meanings given in the description for controlling animal pests, in particular nematodes.

  本发明涉及使用一种具有一般式(I)的化合物，其中M和D具有描述中给出的含义，用于控制动物害虫，特别是线虫。