咪噻吩 | 7187-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并咪唑类化合物
• 中文名称: 咪噻吩
• 英文名称: Trimethaphan
• 英文别名: 1,3-dibenzyl-2-oxo-(3ar,8aξ,8bc)-decahydro-thieno[1',2':1,2]thieno[3,4-d]imidazolium；(+)-4,6-Dibenzyl-5-oxo-1-thionia-4,6-diaza-tricyclo<6.3.0.0/3.7>undecan；3,5-dibenzyl-8-thionia-3,5-diazatricyclo[6.3.0.02,6]undecan-4-one
• CAS: 7187-66-8
• 化学式: C₂₂H₂₅N₂OS
• 分子量: 365.519
• InChiKey: CHQOEHPMXSHGCL-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid
• 溶解度：
  In water, 66.8 mg/L at 25 °C (est)
• 蒸汽压力：
  3.74X10-10 mm Hg at 25 °C (est)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  24.6
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

毒理性

• 相互作用

三甲沙坦可能会延长诸如氯化筒箭毒碱或氯化琥珀胆碱等神经肌肉阻断剂的作用，尤其是在给予大剂量三甲沙坦时。

Trimethaphan may prolong the effects of neuromuscular blocking agents such as tubocurarine chloride or succinylcholine chloride, especially when large doses of trimethaphan are administered.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

普鲁卡因酰胺与三甲沙坦具有叠加的降压作用。

Procainamide has an additive hypotensive effect with trimethaphan.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

三甲沙坦在与麻醉剂联合使用时可能具有附加的降压效果，尤其是脊髓麻醉剂。氟烷和三甲沙坦具有附加的降压效果，这被用于治疗上的优势。一般来说，麻醉的层面越深，产生低血压所需的三甲沙坦剂量越小；相反，在诱导低血压之后，所需的麻醉剂量会更少。

Trimethaphan may have an additive hypotensive effect when administered with anesthetic agents, especially spinal anesthetics. Halothane and trimethaphan have an additive hypotensive effect which is used to therapeutic advantage. In general, the deeper the plane of anesthesia, the smaller the dose of trimethaphan required to produce hypotension; conversely, less anesthetic is required after hypotension has been induced.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

当三甲沙坦与利尿剂或其他降压药同时使用时，三甲沙坦的降压效果可能会增加。

When trimethaphan is administered with diuretics or other hypotensive agents, the hypotensive effect of trimethaphan may be increased.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者向前倾或将其置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

三甲氧苯穿过胎盘。该药物可能被假胆碱酯酶代谢，并由肾脏过滤和积极分泌。

Trimethaphan crosses the placenta. The drug may be metabolized by pseudocholinesterase and is filtered and actively secreted by the kidneys.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

动物研究表明，三甲酚酣camsylate在口服给药后吸收不稳定且不完全。

Animal studies indicate that trimethaphan camsylate is erratically and incompletely absorbed after oral administration.

来源:Hazardous Substances Data Bank (HSDB)