喹啉-8-基氧基膦酸 | 7220-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 喹啉-8-基氧基膦酸
• 英文名称: 8-Quinolinyl phosphate
• 英文别名: phosphoric acid mono-quinolin-8-yl ester；<8>Chinolyl-phosphat；8-Chinolyl-dihydrogenphosphat；Chinolinoyl-8-phosphat；8-Chinolylphosphat；Quinolin-8-yl dihydrogen phosphate
• CAS: 7220-39-5
• 化学式: C₉H₈NO₄P
• 分子量: 225.141
• InChiKey: ZECSTTAOTMSGAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  5

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  8-羟基喹啉	8-quinolinol	148-24-3	C9H7NO	145.161

反应信息

• 作为产物：
  描述：

  8-羟基喹啉 在 4-二甲氨基吡啶 、 t-butylphosphite bound on the Wang resin A 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 乙腈 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 喹啉-8-基氧基膦酸
  参考文献：
  名称：

  Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein

  摘要：

  Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Sre SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00140-3
• 作为试剂：
  描述：

  环己醇 在 喹啉-8-基氧基膦酸 、 copper dichloride 作用下， 生成 cyclohexyl dihydrogen phosphate
  参考文献：
  名称：

  Preparation of Phosphate and Pyrophosphate Esters by the Metal-catalyzed Reaction of 8-Quinolyl Phosphates

  摘要：

  在 Cu (II) 离子存在下，烷基 8-喹啉基氢磷酸酯（烷基=乙基、环己基和苄基）在无水吡啶中转化为相应的 P1、P2-二取代焦磷酸盐，并形成 8-羟基喹啉-Cu (II) 螯合物。当该反应在含有醇（R'=乙基、戊基、环己基和苄基）的吡啶中进行时，相应的二烷基氢磷酸盐（R-R'=乙基-环己基、戊基-环己基、环己基-苄基和乙基-苄基）作为唯一产物生成。研究了影响这种金属催化反应的因素（含水量、溶剂、金属离子），并提出了反应的可能机理。

  DOI：

  10.1248/cpb.21.2438

文献信息

• OLIGODEOXYRIBONUCLEOTIDES
  申请人：Shudo, Koichi, Prof. Dr.

  公开号：EP0540742A1

  公开（公告）日：1993-05-12

  An oligodeoxynucleotide including an oligonucleotide comprising 5' - phosphates of a nucleoside, formed by combining 2 - deoxy - L - erythro- pentose with a nucleic acid base in the form of a β- anomer, linked with each other through 3'-5' phosphodiester linkages; and another oligodeoxynucleotide including an oligonucleotide comprising 5'-phosphates of a nucleoside, formed by combining 2 - deoxy - D - ribose with a nucleic acid base in the form of a β- anomer, and 5' - phosphates of another nucleoside, formed by combining 2 - deoxy - L - erythro- pentose with a nucleic acid base in the form of a β- anomer, linked with each other alternatingly through 3'-5' phosphodiester linkages. Each of the oligodeoxynucleotides combines specifically with a natural oligonucleotide having a complementary base sequence and is useful as an antisense DNA having an activity of inhibiting gene expression. These oligodeoxynucleotides can be efficiently produced by the solid phase method using a phosphoramidite derivative containing a 2-deoxy-β- L-erythro-pentofuranosyl moiety.

  一种寡核苷酸，包括包含5'-核苷酸磷酸的寡核苷酸，由将2'-去氧-L-赤霉糖与以β-异构体形式的核酸碱基结合而成，通过3'-5'磷酸二酯键连接在一起；另一种寡核苷酸，包括包含5'-核苷酸磷酸的寡核苷酸，由将2'-去氧-D-核糖与以β-异构体形式的核酸碱基结合而成，并且由将2'-去氧-L-赤霉糖与以β-异构体形式的核酸碱基结合而成的另一个核苷酸磷酸连接在一起，通过3'-5'磷酸二酯键交替连接在一起。这些寡核苷酸分别与具有互补碱基序列的天然寡核苷酸特异结合，并可用作具有抑制基因表达活性的反义DNA。这些寡核苷酸可以通过使用含有2'-去氧-β-L-赤霉糖基团的磷酰胺酰胺衍生物的固相法高效制备。
• [EN] METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ POUR TRAITER DES INFECTIONS BACTÉRIENNES RÉSISTANT AU MÉDICAMENT ET D'AUTRES INFECTIONS PAR DU CLIOQUINOL, DE LA PHANQUINONE ET DES COMPOSÉS APPARENTÉS
  申请人：XILINAS MICHEL E

  公开号：WO2009140215A2

  公开（公告）日：2009-11-19

  The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.
• Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein
  作者：Pierre Deprez、Eliane Mandine、Dominique Gofflo、Stéphane Meunier、Dominique Lesuisse

  DOI：10.1016/s0960-894x(02)00140-3

  日期：2002.5

  Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Sre SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised. (C) 2002 Elsevier Science Ltd. All rights reserved.

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