喹诺酮 165 | 26078-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 喹诺酮 165
• 中文别名: 7-二甲基氨基-4-甲基-2-羟基喹啉；喹诺酮165
• 英文名称: 4-Methyl-7-dimethylaminocarbostyryl
• 英文别名: carbostyril-165；7-dimethylamino-4-methylquinolin-2(1H)-one；2(1H)-Quinolinone, 7-(dimethylamino)-4-methyl-；7-(dimethylamino)-4-methyl-1H-quinolin-2-one
• CAS: 26078-23-9
• 化学式: C₁₂H₁₄N₂O
• mdl: MFCD00051343
• 分子量: 202.256
• InChiKey: LHWKOWLGYNIFSM-UHFFFAOYSA-N

物化性质

• 沸点：
  340.37°C (rough estimate)
• 密度：
  1.0838 (rough estimate)
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  2933499090

SDS

Name:	Carbostyril 165 laser grade 99+%(uv-vis) Material Safety Data Sheet
Synonym:	2(1H)-Quinolinone, 7-(dimethylamino)-4-methyl-; 7-Dimethylamino-4-methylcarbostyri
CAS:	26078-23-9

Section 1 - Chemical Product MSDS Name:Carbostyril 165 laser grade 99+%(uv-vis) Material Safety Data Sheet
Synonym:2(1H)-Quinolinone, 7-(dimethylamino)-4-methyl-; 7-Dimethylamino-4-methylcarbostyri

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
26078-23-9	Carbostyril 165, laser grade	99+%	247-444-3

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 26078-23-9: Personal Protective Equipment Eyes: Wear chemical splash goggles. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 270-272 C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C12H14N2O
Molecular Weight: 202.26

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials, dust generation, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 26078-23-9 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Carbostyril 165, laser grade - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 26078-23-9: No information available.
Canada
CAS# 26078-23-9 is listed on Canada's NDSL List.
CAS# 26078-23-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 26078-23-9 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

上下游信息

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	(7-dimethylamino-4-methyl-2-oxoquinolin-1(2H)-yl)acetaldehyde	917836-31-8	C14H16N2O2	244.293
  ——	1-(1,3-dioxolan-2-ylmethyl)-7-dimethylamino-4-methylquinolin-2(1H)-one	917835-13-3	C16H20N2O3	288.346

反应信息

• 作为反应物：
  描述：

  喹诺酮 165 在 水 、 sodium hydride 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 144.5h， 生成 (7-dimethylamino-4-methyl-2-oxoquinolin-1(2H)-yl)acetaldehyde
  参考文献：
  名称：

  EP1900732

  摘要：

  公开号：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 喹诺酮 165
  参考文献：
  名称：

  DE958647

  摘要：

  公开号：

文献信息

• NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF
  申请人：Kiyoto Taro

  公开号：US20100168418A1

  公开（公告）日：2010-07-01

  A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R 1 , R 2 , R 3 , R 4 and R 5 independently represent a hydrogen atom, halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclic heterocyclic group which may be substituted or the like; R 6 represents a lower alkyl, aryl, monocyclic heterocyclic, bicyclic heterocyclic or tricyclic heterocyclic group which may be substituted; X 1 represents a lower alkylene group or the like; X 2 represents a lower alkylene, lower alkenylene or lower alkynylene group which may be substituted; X 3 represents an oxygen atom, sulfur atom, a sulfinyl group, sulfonyl group or the like; Y 1 represents a bivalent cyclic group, containing a nitrogen, which may be substituted or the like; and Z 1 represents a nitrogen atom, a carbon atom which may be substituted or the like, or a salt thereof. The compound or salt has a potent antibacterial activity and a high safety, and is therefore useful as an excellent antibacterial agent.

  一种含氮杂环化合物，通式如下：其中虚线代表单键或双键；R1、R2、R3、R4和R5分别独立地代表氢原子、卤素原子、较低的烷基、芳基、较低的烷氧基或可以被取代的单环杂环基等；R6代表较低的烷基、芳基、单环杂环、双环杂环或三环杂环基，可以被取代；X1代表较低的烷基亚基或类似物；X2代表可以被取代的较低烷基、较低烯基或较低炔基亚基；X3代表氧原子、硫原子、亚砜基、磺酰基或类似物；Y1代表含有氮的二价环状基团，可以被取代或类似物；Z1代表氮原子、可以被取代的碳原子或类似物，或其盐。该化合物或盐具有强效的抗菌活性和高度的安全性，因此可用作优良的抗菌剂。
• QUINOLINONES AND QUINOXALINONES AS ANTIBACTERIAL COMPOSITION
  申请人：KIYOTO Taro

  公开号：US20120214990A1

  公开（公告）日：2012-08-23

  A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

  一种含氮杂环化合物，或其药学上可接受的盐，其通式如下：具有强效的抗菌活性和高安全性。因此，这些化合物可用作抗革兰阳性菌、抗革兰阴性菌和抗药性菌的抗菌剂。
• Electroluminescent device with modified thin film luminescent zone
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0281381A2

  公开（公告）日：1988-09-07

  An electroluminescent device is disclosed having a luminescent zone of less than one µm in thickness comprised of an organic host material capa­ble of sustaining hole-electron recombination and a fluorescent material capable of emitting light in response to energy released by hole-electron recombi­nation.

  本发明公开了一种电致发光器件，该器件具有厚度小于 1 微米的发光区，发光区由能够维持空穴-电子重组的有机主材料和能够响应空穴-电子重组释放的能量而发光的荧光材料组成。
• PHOTOSENSITIVE POLYSILAZANE COMPOSITION AND METHOD OF FORMING PATTERNED POLYSILAZANE FILM
  申请人：TonenGeneral Sekiyu K.K.

  公开号：EP1164435A1

  公开（公告）日：2001-12-19

  A photosensitive polysilazane which may be used as a positive-tone photoresist, and a method of forming a patterned polysilazane film by use of such a composition are provided. The photosensitive polysilazane composition of the invention is characterized by comprising a polysilazane, particularly polymethylsilazane or polyphenylsilazane, and an optically acid-generating agent. The patterned polysilazane film is obtained by exposing a coating of the photosensitive polysilazane composition of the invention to light in a pattern and dissolving off the exposed portion.

  本发明提供了一种可用作正色调光刻胶的光敏聚硅氮烷，以及使用这种组合物形成图案化聚硅氮烷薄膜的方法。本发明的光敏聚硅氮烷组合物的特点是由一种聚硅氮烷（特别是聚甲基硅氮烷或聚苯基硅氮烷）和一种光学酸生成剂组成。将本发明的光敏聚硅氮烷组合物涂层按一定图案对光照射，然后溶解掉照射部分，即可得到图案化的聚硅氮烷薄膜。
• Polycarbonate compositions with improved molding capability
  申请人：SABIC Innovative Plastics IP B.V.

  公开号：EP2292693A1

  公开（公告）日：2011-03-09

  A thermoplastic composition comprising a polycarbonate, a polycarbonate-polysiloxane copolymer, an impact modifier composition comprising ABS or BABS, a second impact modifier different from BABS or ABS, and an aromatic vinyl copolymer is disclosed. The thermoplastic composition has improved molding capability.

  本发明公开了一种热塑性塑料组合物，该组合物包括聚碳酸酯、聚碳酸酯-聚硅氧烷共聚物、由 ABS 或 BABS 组成的抗冲击改性剂组合物、不同于 BABS 或 ABS 的第二抗冲击改性剂以及芳香族乙烯基共聚物。该热塑性组合物具有更好的成型能力。