6,7-ethylenedioxy-1H-pyrazolo[3,4-b]quinoline-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6,7-ethylenedioxy-1H-pyrazolo[3,4-b]quinoline-3-amine
• 英文别名: 4,7-Dioxa-11,13,14-triazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),2,8,10,12,15-hexaen-15-amine
• 化学式: C₁₂H₁₀N₄O₂
• 分子量: 242.237
• InChiKey: GODRXFLHORTKTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6,7-ethylenedioxy-1H-pyrazolo[3,4-b]quinoline-3-amine 、 3-氯苯甲酰氯 在 三乙胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以69%的产率得到3-chloro-N-(6,7-methylenedioxy-1H-pyrazolo[3,4-b]quinolin-3-yl)benzamide
  参考文献：
  名称：

  Regioselective acylation of congeners of 3-amino-1H-pyrazolo[3,4-b]quinolines, their activity on bacterial serine/threonine protein kinases and in vitro antibacterial (including antimycobacterial) activity

  摘要：

  It was found by virtual screening that 3-amino-1H-pyrazolo[3,4-b]quinolines could have wide protein kinase inhibitory activity. Amides of titled amines and thioureas were synthesized regioselectively. 3-Amino-7-methoxy-1Hpyrazolo[3,4-b]quinoline demonstrated in vitro significant inhibitory activity on bacterial serine/threonine protein kinases (inhibition of resistance to kanamycin in Streptomyces lividans regulated by protein kinases). The studies of Structure Activity Relationship (SAR) showed that the substitution of the NH2 group and 1-NH of pyrazole ring or aromatic ring at the position 6 decreased or removed inhibitory activity.

  DOI：

  10.3109/14756366.2012.716056
• 作为产物：
  描述：

  7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline-8-carbonitrile 在 一水合肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以89%的产率得到6,7-ethylenedioxy-1H-pyrazolo[3,4-b]quinoline-3-amine
  参考文献：
  名称：

  Regioselective acylation of congeners of 3-amino-1H-pyrazolo[3,4-b]quinolines, their activity on bacterial serine/threonine protein kinases and in vitro antibacterial (including antimycobacterial) activity

  摘要：

  It was found by virtual screening that 3-amino-1H-pyrazolo[3,4-b]quinolines could have wide protein kinase inhibitory activity. Amides of titled amines and thioureas were synthesized regioselectively. 3-Amino-7-methoxy-1Hpyrazolo[3,4-b]quinoline demonstrated in vitro significant inhibitory activity on bacterial serine/threonine protein kinases (inhibition of resistance to kanamycin in Streptomyces lividans regulated by protein kinases). The studies of Structure Activity Relationship (SAR) showed that the substitution of the NH2 group and 1-NH of pyrazole ring or aromatic ring at the position 6 decreased or removed inhibitory activity.

  DOI：

  10.3109/14756366.2012.716056

文献信息

• Regioselective acylation of congeners of 3-amino-1H-pyrazolo[3,4-b]quinolines, their activity on bacterial serine/threonine protein kinases and in vitro antibacterial (including antimycobacterial) activity
  作者：Gennady B. Lapa、O. B. Bekker、E. P. Mirchink、V. N. Danilenko、M. N. Preobrazhenskaya

  DOI：10.3109/14756366.2012.716056

  日期：2013.10.1

  It was found by virtual screening that 3-amino-1H-pyrazolo[3,4-b]quinolines could have wide protein kinase inhibitory activity. Amides of titled amines and thioureas were synthesized regioselectively. 3-Amino-7-methoxy-1Hpyrazolo[3,4-b]quinoline demonstrated in vitro significant inhibitory activity on bacterial serine/threonine protein kinases (inhibition of resistance to kanamycin in Streptomyces lividans regulated by protein kinases). The studies of Structure Activity Relationship (SAR) showed that the substitution of the NH2 group and 1-NH of pyrazole ring or aromatic ring at the position 6 decreased or removed inhibitory activity.