cis-2-methyl-N-phenyl-1,2,3,4-tetrahydro-4-quinolinamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: cis-2-methyl-N-phenyl-1,2,3,4-tetrahydro-4-quinolinamine
• 英文别名: (2S,4R)-2-methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine
• 化学式: C₁₆H₁₈N₂
• 分子量: 238.332
• InChiKey: FTECJLOPKLYFII-BLLLJJGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-2-methyl-N-phenyl-1,2,3,4-tetrahydro-4-quinolinamine 、 吡啶-2-甲酰氯盐酸盐 在 ice 、 水 、 ethyl acetate n-hexane 作用下， 以 吡啶 、 乙酸乙酯 为溶剂， 反应 16.0h， 以134 mg (yield, 19%) of the product, cis-2-methyl-N-phenyl-1-(2-pyridinylcarbonyl)-1,2,3,4-tetrahydro-4-quinolinamine as white crystals的产率得到cis-2-methyl-N-phenyl-1-(2-pyridinylcarbonyl)-1,2,3,4-tetrahydro-4-quinolinamine
  参考文献：
  名称：

  Soluble beta amyloid precursor protein secretion promoters

  摘要：

  根据本发明，提供了由式(I)表示的化合物：1［其中，R1和R2表示氢原子、较低的烷基等；环A是可选的取代苯环，X是氧原子等；Y表示CH或N］或其盐、前药，以及使用这些化合物的方法和制造这些化合物的过程。本发明中的化合物等具有强大的可溶性β淀粉样前体蛋白分泌促进活性，并抑制由具有神经营养因子样性质的分泌的可溶性β淀粉样前体蛋白介导的细胞功能障碍或凋亡，特别是神经元。

  公开号：

  US20030216398A1
• 作为产物：
  描述：

  乙炔 、 苯胺 、 氯化汞(II) 生成 cis-2-methyl-N-phenyl-1,2,3,4-tetrahydro-4-quinolinamine
  参考文献：
  名称：

  BARLUENGA J.; AZNAR F.; LIZ R.; RODES R., J. CHEM. SOC. PERKIN TRANS., PART 1, 1980, NO 12, 2732-2737

  摘要：

  DOI：

文献信息

• COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR
  申请人：HUMAN BIOMOLECULAR RESEARCH INSTITUTE

  公开号：US20160038641A1

  公开（公告）日：2016-02-11

  Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, transdifferentiation, and proliferation of animal cells into the osteoblast blast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

  描述了由小分子、基质和孤立细胞组成的组合物，包括制备方法，以及动物细胞分化、转分化和增殖成骨母细胞谱系的方法。给细胞施加的或与细胞共培养的成骨材料的示例由独立或首选与基质组合的Formula II、IV和VI化合物代表。受小分子刺激的细胞还与基质结合，与细胞粘合剂或材料载体一起植入到动物体内的部位进行骨修复。预先用Formula II、IV和VI化合物处理的基质也被用于导致细胞迁移到用于治疗目的的基质上。
• [EN] TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX<br/>[FR] TETRAHYDROQUINOLINES DESTINEES A MODULER L'EXPRESSION DE GENES EXOGENES PAR LE BIAIS D'UN COMPLEXE DE RECEPTEURS DE L'ECDYSONE
  申请人：RHEOGENE INC

  公开号：WO2003105849A1

  公开（公告）日：2003-12-24

  This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of 4-tetrahydorquinolines.

  本发明涉及一种调节外源基因表达的方法，其中包括接触由DNA结合域、配体结合域、转录激活域和配体组成的ecdysone受体复合物，并与包括外源基因和响应元件的DNA构建物接触；其中，外源基因受响应元件控制，DNA结合域在配体存在下与响应元件结合导致基因的激活或抑制。配体包括一类4-四氢喹啉。
• PGD2 receptor antagonists for the treatment of inflammatory diseases
  申请人：Ghosh Shomir

  公开号：US20060106061A1

  公开（公告）日：2006-05-18

  Disclosed herein are compounds represented by Structural Formula (I): (I), wherein the variables are defined herein. Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 (“CRTH2”) for the treatment of inflammatory disorders.

  本文披露了由结构式（I）表示的化合物：（I），其中变量在此定义。还披露了使用这些化合物抑制称为Th2上表达的趋化因子受体同源分子的G蛋白偶联受体（“CRTH2”）治疗炎症性疾病的方法。
• TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX
  申请人：Michelotti Enrique

  公开号：US20050228016A1

  公开（公告）日：2005-10-13

  This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of 4-tetrahydroquinolines.

  本发明涉及一种调节外源基因表达的方法，其中包括一个包含：DNA结合域、配体结合域、转录激活域和配体的ecdysone受体复合物与包括：外源基因和响应元件的DNA构建物接触；其中外源基因受响应元件控制，在存在配体的情况下，DNA结合域与响应元件的结合会导致基因的激活或抑制。配体包括一类4-四氢喹啉。
• SOLUBLE BETA AMYLOID PRECURSOR PROTEIN SECRETION PROMOTERS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1283055A1

  公开（公告）日：2003-02-12

  According to the present invention, there are provided compounds represented by formula (I): [wherein R1 and R2 represent hydrogen atom, a lower alkyl group, etc.; ring A is an optionally substituted benzene ring, X is oxygen atom, etc.; and Y represents CH or N] or salts thereof, or prodrugs thereof, and use thereof as well as processes of manufacturing these compounds. The compounds of the present invention and the like possess a potent soluble beta amyloid precursor protein secretion promoting activity and suppress the functional disorders or apoptosis of cells, in particular neurons, mediated by the secreted soluble beta amyloid precursor proteins having a neurotrophic factor like property.

  根据本发明，提供了式(I)代表的化合物： [其中 R1 和 R2 代表氢原子、低级烷基等；环 A 是任选取代的苯环，X 是氧原子等；Y 代表 CH 或 N]或其盐或其原药及其用途以及制造这些化合物的工艺。本发明的化合物及其类似物具有强效的可溶性β淀粉样前体蛋白分泌促进活性，可抑制由分泌的具有类似神经营养因子特性的可溶性β淀粉样前体蛋白介导的细胞，特别是神经元的功能紊乱或凋亡。