8-hydroxyquinoline-7-carbonyl chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-hydroxyquinoline-7-carbonyl chloride
• 化学式: C₁₀H₆ClNO₂
• 分子量: 207.616
• InChiKey: DORISJPSDHZAQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-hydroxyquinoline-7-carbonyl chloride 、 氨基乙腈 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 N-(cyanomethyl)-8-hydroxy-7-quinolinecarboxamide
  参考文献：
  名称：

  Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors

  摘要：

  A new series of potent 8-hydroxyquinolines was designed based on the newly resolved X-ray crystal structure of EGLN-1. Both alkyl and aryl 8-hydroxyquinoline-7-carboxyamides were good HIF-1 alpha prolyl hydroxylase (EGLN) inhibitors. In subsequent VEGF induction assays, these exhibited potent VEGF activity. In addition, this class of compounds did show the ability to stabilize HIF-1 alpha. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.040
• 作为产物：
  描述：

  8-羟基喹啉-7-羧酸 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 8-hydroxyquinoline-7-carbonyl chloride
  参考文献：
  名称：

  New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof

  摘要：

  新的三级8-羟基喹啉-7-甲酰胺衍生物的一般化学式（I）及其药用盐已被披露。 这些化合物可用作抗真菌剂。具体来说，这些化合物已对白色念珠菌、白色念珠菌、黑曲霉和短柄曲霉进行了测试。这些化合物也对白色念珠菌属的物种如白色念珠菌和光滑白色念珠菌具有活性。

  公开号：

  EP2345643A1

文献信息

• New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
  申请人：POLICHEM S.A.

  公开号：EP2345643A1

  公开（公告）日：2011-07-20

  New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.

  新的三级8-羟基喹啉-7-甲酰胺衍生物的一般化学式（I）及其药用盐已被披露。 这些化合物可用作抗真菌剂。具体来说，这些化合物已对白色念珠菌、白色念珠菌、黑曲霉和短柄曲霉进行了测试。这些化合物也对白色念珠菌属的物种如白色念珠菌和光滑白色念珠菌具有活性。
• [EN] NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE TERTIAIRES ET LEURS UTILISATIONS
  申请人：POLICHEM SA

  公开号：WO2011080264A1

  公开（公告）日：2011-07-07

  New tertiary 8-hydroxyquinoiine-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.

  新的三级8-羟基喹啉-7-甲酰胺衍生物的一般式（I）及其药用盐已被披露。这些化合物可用作抗真菌剂。具体来说，这些化合物已对白色念珠菌、小耳癣菌、黑曲霉和短柄镰刀菌进行了测试。这些化合物也对白色念珠菌属如白色念珠菌和光滑白色念珠菌具有活性。
• TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF
  申请人：Gagliardi Stefania

  公开号：US20120309751A1

  公开（公告）日：2012-12-06

  New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis . These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.

  公式（I）的新三级8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐被揭示。这些化合物可用作抗真菌剂。具体而言，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。这些化合物也对Candida Albicans和Candida Glabrata等Candida物种具有活性。
• Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
  申请人：Gagliardi Stefania

  公开号：US08729098B2

  公开（公告）日：2014-05-20

  New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明涉及一种新的三级8-羟基喹啉-7-羧酰胺衍生物，其通式为(I)，以及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体而言，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。这些化合物对Candida Albicans和Candida Glabrata等念珠菌也具有活性。
• NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF
  申请人：Polichem SA

  公开号：EP2519505A1

  公开（公告）日：2012-11-07