1,4-bis(3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione-9-yl)benzene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,4-bis(3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione-9-yl)benzene
• 英文别名: 3,3,6,6-Tetramethyl-9-[4-(3,3,6,6-tetramethyl-1,8-dioxo-2,4,5,7,9,10-hexahydroacridin-9-yl)phenyl]-2,4,5,7,9,10-hexahydroacridine-1,8-dione
• 化学式: C₄₀H₄₈N₂O₄
• 分子量: 620.832
• InChiKey: DYRHUKKNWAGZSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  46
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  92.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对苯二甲醛 、 5,5-二甲基-1,3-环己二酮 在 1-methylimidazolium tricyanomethanide 、 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.25h， 以95%的产率得到1,4-bis(3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione-9-yl)benzene
  参考文献：
  名称：

  一种使用1-甲基咪唑三氰胺{[HMIM] C（CN）3 }作为纳米结构熔融盐催化剂合成1,8-二氧杂硼氢化hydro啶衍生物的简便方法

  摘要：

  达到为1,8- dioxodecahydroacridine衍生物的合成的实用和方便的方法通过在1-甲基咪唑三氰基{[HMIM存在环状1,3-二酮，醛和各种苯胺或乙酸铵的一锅缩合反应] C（CN）3 }在室温下为纳米结构熔盐（NMS）催化剂。在目前的工作中，将首次报告三十多种产品。

  DOI：

  10.1016/j.molliq.2016.03.006

文献信息

• New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation
  作者：Shujiang Tu、Chunbao Miao、Fang Fang、Feng Youjian、Tuanjie Li、Qiya Zhuang、Xiaojing Zhang、Songlei Zhu、Daqing Shi

  DOI：10.1016/j.bmcl.2003.12.092

  日期：2004.3

  The synthesis of bifunctional pyridine, pyrimidine, pyridone, quinoline and acridine derivatives was investigated using dialdehyde as a precursor. A rapid and efficient method was developed for the synthesis of a range of bifunctional monocyclic, bicyclic and tricyclic products related to 1,4-DHPs with the aim of finding new classes of biologically active compounds.

  以二醛为前驱体研究了双功能吡啶，嘧啶，吡啶酮，喹啉和a啶衍生物的合成。为了发现新型的生物活性化合物，开发了一种快速有效的方法来合成一系列与1,4-DHPs有关的双功能单环，双环和三环产品。
• A Novel Cascade Reaction of Aryl Aldoxime with Dimedone Under Microwave Irradiation: The Synthesis of<i>N</i>-Hydroxylacridine
  作者：Shujiang Tu、Chunbao Miao、Yuan Gao、Fang Fang、Qiya Zhuang、Youjian Feng、Daqing Shi

  DOI：10.1055/s-2003-44981

  日期：——

  A novel sequential addition, elimination and cyclization reactions took place when aldoxime and dimedone in glycol was subjected to microwave irradiation and a new type of N-hydroxyl­acridinedione derivatives was obtained in excellent yields (80-95%) within a short reaction time (4-8 min).

  在微波辐照下，乙二醇中的醛肟和二咪酮发生了新的顺序加成、消除和环化反应，并在很短的反应时间（4-8 分钟）内获得了一种新型的 N-羟基吖啶二酮衍生物，收率极高（80-95%）。
• The Reaction of Aromatic Dialdehyde with Dimedone Under Microwave Irradiation
  作者：Shujiang Tu、Yuan Gao、Chunbao Miao、Songlei Zhu、Tuanjie Li、Xiaojing Zhang、Daqing Shi

  DOI：10.1081/scc-200025623

  日期：2004.1.1

  The bis-oxanthene, bis-polyhydroacridine, and bis-N-hydroxylacridine derivatives were obtained by the reaction of aromatic dialdehyde with dimedone in ethylene glycol under microwave irradiation. The reaction time was shot and the yield was high.
• A convenient method for the synthesis of 1,8-dioxodecahydroacridine derivatives using 1-methylimidazolium tricyanomethanide {[HMIM]C(CN)3} as a nanostructured molten salt catalyst
  作者：Mohammad Ali Zolfigol、Neda Bahrami-Nejad、Saeed Baghery

  DOI：10.1016/j.molliq.2016.03.006

  日期：2016.6

  A practical and convenient method for the synthesis of 1,8-dioxodecahydroacridine derivatives was achieved via the one-pot condensation reaction of cyclic 1,3-diketone, aldehydes and various anilines or ammonium acetate in the presence of 1-methylimidazolium tricyanomethanide [HMIM]C(CN)3} as a nanostructured molten salt (NMS) catalyst at room temperature. In the present work, more than thirty products

  达到为1,8- dioxodecahydroacridine衍生物的合成的实用和方便的方法通过在1-甲基咪唑三氰基[HMIM存在环状1,3-二酮，醛和各种苯胺或乙酸铵的一锅缩合反应] C（CN）3 }在室温下为纳米结构熔盐（NMS）催化剂。在目前的工作中，将首次报告三十多种产品。