土波台文碱 | 6711-69-9

• 物质功能分类: 天然产物 - 生物碱
• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 马钱子生物碱
• 中文名称: 土波台文碱
• 英文名称: tubotaiwine
• 英文别名: 20(S)-tubotaiwine；methyl (1S,11S,17R,18S)-18-ethyl-8,14-diazapentacyclo[9.5.2.01,9.02,7.014,17]octadeca-2,4,6,9-tetraene-10-carboxylate
• CAS: 6711-69-9
• 化学式: C₂₀H₂₄N₂O₂
• 分子量: 324.423
• InChiKey: RLAKWLFUMAABBE-STJTYLQHSA-N

物化性质

• 沸点：
  467.7±45.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (+)-condylocarpine 在 platinum(IV) oxide 、 氢气 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以91%的产率得到土波台文碱
  参考文献：
  名称：

  (+)-Condylocarpine、(+)-Isocondylocarpine 和 (+)-Tubotaiwine 的全合成

  摘要：

  报道了第一个对映选择性全合成的髁果类吲哚生物碱。(+)-Condylocarpine、(+)-isocondylocarpine 和 (+)-tubotaiwine 从 (1 S ,5 R )-hexahydro-1,5-methano-1 H以高对映体纯度 (er > 99:1) 制备-azocino[4,3 - b ]indole-12-one 7b通过五个或六个分离的中间体。

  DOI：

  10.1021/ol102709s

文献信息

• METHOD AND MEANS FOR MANUFACTURING TERPENE INDOLE ALKALOIDS
  申请人：JOHN INNES CENTRE

  公开号：EP3765467A1

  公开（公告）日：2021-01-20
• IBOGAINE FORMULATIONS
  申请人：Caamtech, LLC

  公开号：EP3986415A1

  公开（公告）日：2022-04-27
• BIOMARKERS FOR MALARIA DIAGNOSIS
  申请人：The United States of America, as represented by the Secretary, Dept. of Health and Human Services

  公开号：US20180052161A1

  公开（公告）日：2018-02-22

  Disclosed herein are methods of detecting Plasmodium in a subject (for example, presence of Plasmodium parasite) by detecting the presence and/or amount of one or more metabolites in a sample from the subject. In some embodiments, the methods include detecting in the sample one or more metabolites listed in Table 1, Table 2, and/or Tables 5-8. The amount of the one or more metabolites in the sample is compared to the amount of the one or more metabolites in a control and presence of Plasmodium is determined if the amount of the one or more metabolites is different (for example statistically significantly increased or decreased) compared to the control.
• [EN] PRODUCTION OF PLANT SECONDARY METABOLITES USING ADSORPTION AND ELICITATION IN CELL SUSPENSION CULTURE<br/>[FR] PRODUCTION DE METABOLITES SECONDAIRES VEGETAUX PAR ASBORPTION ET ELICITATION DANS UNE CULTURE CELLULAIRE EN SUSPENSION
  申请人：UNIV MELBOURNE

  公开号：WO2005012507A1

  公开（公告）日：2005-02-10

  The invention discloses a method of producing a plant secondary metabolite of interest,comprising: (a) cultivating by suspension culture in a suitable nutrient medium plant cells that produce the secondary metabolite; (b) including within the suspension culture an amount of adsorbent and one or more elicitor agents suitable to increase production of the secondary metabolite; (c)recovering the secondary metabolite from the suspension culture. In a preferred emobidment the invention discloses a method of producing a stilbene plant secondary metabolite of interest, comprising: (a) cultivating by suspension culture in a suitable nutrient medium plant cells that produce a stilbene secondary metabolite; (b) including within the suspension culture an amount of adsorbent and one or more elicitor agents suitable to increase production of the stilbene; (c) recovering the stilbene from the suspension culture.
• [EN] METHOD AND MEANS FOR MANUFACTURING TERPENE INDOLE ALKALOIDS<br/>[FR] PROCÉDÉ ET MOYEN DE FABRICATION D'ALCALOÏDES DE TERPÈNE-INDOLE
  申请人：INNES JOHN CENTRE

  公开号：WO2019175607A1

  公开（公告）日：2019-09-19

  The complex chemistry underlying the extensive transformations involved in terpene indole alkaloid synthesis makes identification of the biosynthetic genes challenging. The present invention relates to methods for producing a terpene indole alkaloid derivative, comprising the steps of: (1) providing a terpene indole alkaloid; and (2) providing a first enzyme termed "Precondylocarpine Acetate Synthase" (PAS) or a functional variant or homologue thereof; and/or a second enzyme termed "Dehydroprecondylocarpine Acetate Synthase" (DPAS) or a functional variant or homologue thereof, and optionally providing further identified enzymes involved in this pathway. The invention also encompasses related kits, enzymes, expression vectors, host cells and plants.