托锡弗林 | 302-30-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 马钱子生物碱
• 中文名称: 托锡弗林
• 英文名称: Toxiferine
• 英文别名: (2E)-2-[(1S,9Z,11S,13S,14S,17S,25Z,27S,30S,33S,35S,36S,38E)-38-(2-hydroxyethylidene)-14,30-dimethyl-8,24-diaza-14,30-diazoniaundecacyclo[25.5.2.211,14.11,26.110,17.02,7.013,17.018,23.030,33.08,35.024,36]octatriaconta-2,4,6,9,18,20,22,25-octaen-28-ylidene]ethanol
• CAS: 302-30-7
• 化学式: C40H46N4O2+2
• 分子量: 614.8
• InChiKey: IIYHWTVUYIYKKG-QQRSFBQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  46
• 可旋转键数：
  2
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

毒理性

• 毒性总结

库拉雷是一种非去极化肌肉松弛剂，它在烟碱型乙酰胆碱受体上作为竞争性拮抗剂发挥作用。

Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

库拉雷是一种肌肉松弛剂，可能导致因窒息而死亡，因为呼吸肌肉无法收缩。

Curare is a muscle relaxant that can lead to death from asphyxiation, as the respiratory muscles are unable to contract. (L1256)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

注射（刺伤/咬伤）

Injection (sting/bite) (L1256)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

库亚雷是一种肌肉松弛剂，因此会导致麻痹。

Curare is a muscle relaxant and thus causes paraylsis. (L1256)

来源:Toxin and Toxin Target Database (T3DB)

文献信息

• Anti-Inflammatory and Anti-Allergy Extracts from Nettle
  申请人：Alberte Randall S.

  公开号：US20100009927A1

  公开（公告）日：2010-01-14

  The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.
• [EN] ANTI-INFLAMMATORY AND ANTI-ALLERGY EXTRACTS FROM NETTLE<br/>[FR] EXTRAITS D'ORTIE ANTI-INFLAMMATOIRES ET ANTIALLERGIQUES
  申请人：HERBALSCIENCE GROUP LLC

  公开号：WO2010009091A2

  公开（公告）日：2010-01-21

  The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.