埃皮塔隆 | 307297-39-8

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 埃皮塔隆
• 英文名称: Epitalon
• 英文别名: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• CAS: 307297-39-8；64082-79-7
• 化学式: C₁₄H₂₂N₄O₉
• 分子量: 390.35
• InChiKey: HGHOBRRUMWJWCU-FXQIFTODSA-N

物化性质

• 沸点：
  959.8±65.0 °C(Predicted)
• 密度：
  1.466±0.06 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜：250 mg/mL（495.67 mM）

计算性质

• 辛醇/水分配系数(LogP)：
  -5.5
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  225
• 氢给体数：
  7
• 氢受体数：
  10

安全信息

• 危险性防范说明：
  P261,P264,P270,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P330,P362,P403+P233,P501
• 危险性描述：
  H302,H312,H332

制备方法与用途

简介

埃皮塔隆是一种人工合成的多肽，被誉为上皮组织的维生素。

应用

最初在牛松果体提取物中被发现，埃皮塔隆作为一种抗衰老药物，在各种化妆品中得到了广泛应用。

储存

为了保持其活性和稳定性，埃皮塔隆应储存在-20℃下进行冷冻干燥，并避免光照。

参考质量标准

• 外观：白色粉末
• 纯度（HPLC）：≥98.0%
• 单杂：≤1.0%
• 醋酸根含量：5.0%～12.0%
• 水分含量：≤10.0%
• 肽含量：≥80.0%

反应信息

• 作为产物：
  描述：

  以95的产率得到埃皮塔隆
  参考文献：
  名称：

  Tetrapetide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application

  摘要：

  提议将L-丙氨酸-L-谷氨酰-L-天冬氨酸-甘氨酸四肽（SEQ ID NO：1）的一般公式L-Ala-L-Glu-L-Asp-Gly（SEQ ID NO：1）作为具有延缓衰老作用的生物活性化合物。建议将L-Ala-L-Glu-L-Asp-Gly（SEQ ID NO：1）四肽在医学上用于制备显示延缓衰老作用的物质。提议一种药理物质，其含有效量的L-丙氨酸-L-谷氨酰-L-天冬氨酸-甘氨酸（L-Ala-L-Glu-L-Asp-Gly）（SEQ ID NO：1）或其氨基（乙酸盐，盐酸盐，草酸盐）和羧基（金属盐-钠，钾，钙，锂，锌，镁，以及有机和无机阳离子的盐-铵和三乙基铵）的盐作为其活性基础。该物质建议用于肌肉注射、鼻腔注射、口服和局部应用。关于本发明，预防和/或治疗老化过早的方法涉及向患者预防性和/或治疗性地施用药理物质，剂量为每天0.01至100μg/kg体重，持续一段时间以达到治疗效果。

  公开号：

  US06727227B1

文献信息

• TETRAPEPTIDE REVEALING GEROPROTECTIVE EFFECT, PHARMACOLOGICAL SUBSTANCE ON ITS BASIS, AND THE METHOD OF ITS APPLICATION
  申请人：Obschestvo s Ogranichennoi Otvetstvennostiju "Klinika Instituta Bioregulyatsii i Gerontologii"

  公开号：EP1179008B1

  公开（公告）日：2006-03-22
• METHOD OF OBTAINING PEPTIDES WITH TISSUE-SPECIFIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASIS
  申请人：Sankt-Peterburgskaya Obschestvennaya Organizatsya "Institut Biroregulyatsii i Gerontologii szo Ramn"

  公开号：EP1294743A2

  公开（公告）日：2003-03-26
• Method of obtaining peptides with tissue-specific activity and pharmaceutical compositions on their basis
  申请人：Khavinson Khatskelevich Vladimir

  公开号：US20050004016A1

  公开（公告）日：2005-01-06

  The invention refers to the field of chemistry and concerns the method of obtaining peptides with tissue-specific activity by targeted chemical synthesis. This invention can be employed in medicine to obtain peptide-based pharmaceuticals normalising the functions of various organs and functions. The method of obtaining peptides proposed in this patent claim embraces quantitative amino acid analysis of acetic extracts from tissues, selection on its basis of two amino acids (Glu and Asp) prevailing in the studied tissue, synthesis of the central link from these amino acids and attachment to its N- and C-ends of the amino acids prevailing among the remaining amino acids in the studied tissue. The peptides obtained by the claimed method possess a tissue-specific activity. There is proposed a pharmaceutical composition possessing a tissue-specific activity and containing as its active base one of the peptides obtained by the claimed method or its salts and a pharmaceutically admissible carrier.
• US6727227B1
  申请人：——

  公开号：US6727227B1

  公开（公告）日：2004-04-27
• [EN] METHOD OF OBTAINING PEPTIDES WITH TISSUE-SPECIFIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASIS<br/>[FR] PROCEDE DE FABRICATION DE PEPTIDES A ACTIVITE SPECIFIQUE AUX TISSUS ET COMPOSITIONS PHARMACEUTIQUES A BASE DE CEUX-CI
  申请人：SANKT PETERBURGSKAYA OBSCHESTV

  公开号：WO2002000684A2

  公开（公告）日：2002-01-03

  The invention refers to the field of chemistry and concerns the method of obtaining peptides with tissue-specific activity by targeted chemical synthesis. This invention can be employed in medicine to obtain peptide-based pharmaceuticals normalising the functions of various organs and functions. The method of obtaining peptides proposed in this patent claim embraces quantitative amino acid analysis of acetic extracts from tissues, selection on its basis of two amino acids (Glu and Asp) prevailing in the studied tissue, synthesis of the central link from these amino acids and attachment to its N- and C-ends of the amino acids prevailing among the remaining amino acids in the studied tissue. The peptides obtained by the claimed method possess a tissue-specific activity. There is proposed a pharmaceutical composition possessing a tissue-specific activity and containing as its active base one of the peptides obtained by the claimed method or its salts and a pharmaceutically admissible carrier.