18-(6-methoxy-1H-indole-3-yl)-octadecane-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 18-(6-methoxy-1H-indole-3-yl)-octadecane-1-ol
• 英文别名: 18-(6-methoxy-1H-indol-3-yl)octadecan-1-ol
• 化学式: C₂₇H₄₅NO₂
• 分子量: 415.66
• InChiKey: OBBQJSHVPWOGSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  30
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  15-溴-1-十五烷醇 在 palladium on activated charcoal disodium hydrogenphosphate 、 sodium amalgam 、 lithium aluminium tetrahydride 、 正丁基锂 、 氢气 、 sodium hydride 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 正己烷 、 二氯甲烷 、 乙腈 为溶剂， -78.0~20.0 ℃ 、101.33 kPa 条件下， 生成 18-(6-methoxy-1H-indole-3-yl)-octadecane-1-ol
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616

文献信息

• Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres
  作者：Djalil Coowar、Julien Bouissac、Mazen Hanbali、Marie Paschaki、Eliane Mohier、Bang Luu

  DOI：10.1021/jm0493616

  日期：2004.12.1

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.