失水甘露醇单油酸酯 | 9049-98-3

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 中文名称: 失水甘露醇单油酸酯
• 中文别名: 二缩甘露醇单油酸酯；阿拉西A
• 英文名称: monooleic acid isosorbide
• 英文别名: Arlacel A；(3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl) (Z)-octadec-9-enoate
• CAS: 9049-98-3
• 化学式: C₂₄H₄₂O₅
• 分子量: 410.594
• InChiKey: JDRAOGVAQOVDEB-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  29
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• WGK Germany：
  3

制备方法与用途

概述

阿拉西A又称为失水甘露醇油酸酯、甘露醇油酸酯，是一种常用的表面活性剂。阿拉西A可以通过一步反应由甘露醇和油酸制备得到。

应用

失水甘露醇单油酸酯作为有机合成中间体和医药中间体，在实验室有机合成过程及化工医药合成过程中有着广泛的应用价值。

文献信息

• CELL STAINING ASSAY AND KIT
  申请人：The Binding Site Group Limited

  公开号：EP2238456A1

  公开（公告）日：2010-10-13
• VACCINE COMPOSITIONS
  申请人：The University Of Sydney

  公开号：EP3710051A1

  公开（公告）日：2020-09-23
• STABLE EMULSIONS OF BACTERIAL ANTIGENS
  申请人：Intervet Inc.

  公开号：US20210378957A1

  公开（公告）日：2021-12-09

  The present invention is based on the discovery of new and advantageous properties of a class of known polymeric emulsifiers. The emulsifier class was found to be resistant to degradation by crude bacterial antigen preparations, which degradation caused emulsion instability when using prior art emulsifiers. This allows the formulation of safe, stable, and effective vaccines based on these emulsions of oil and water comprising such bacterial antigens. The polymeric emulsifier is a block copolymer having a general formula A-B-A in which component B is the divalent residue of a water-soluble polyalkylene glycol and component A is the residue of an oil-soluble complex monocarboxylic acid. Preferred emulsifier is a PEG-30-di-(polyhydroxystearate).
• [EN] CELL STAINING ASSAY AND KIT<br/>[FR] ANALYSE DE COLORATION CELLULAIRE ET KIT
  申请人：BINDING SITE LTD

  公开号：WO2009095665A1

  公开（公告）日：2009-08-06

  The application provides a method of staining one or more cells using an antibody, or a fragment thereof, having specificity for an immunoglobulin heavy chain class, at the same time as having specificity for a light chain type, and detecting the binding of the antibody to the tissue or cells. Tissue or cells staining kits comprising such antibodies are also provided.
• [EN] EMULSION VACCINE FOR FISH<br/>[FR] VACCIN DE TYPE ÉMULSION DESTINÉ AUX POISSONS
  申请人：INTERVET INT BV

  公开号：WO2020078941A1

  公开（公告）日：2020-04-23

  The present invention discloses the new and advantageous properties of an emulsion of water and oil that can be used to prepare an emulsion vaccine for fish which has improved safety properties. The emulsion employs a specific class of polymeric emulsifiers instead of prior art emulsifiers. When used in fish, vaccines based on this adapted emulsion induced a smaller drop in appetite after vaccination, and the vaccinated fish showed a faster recovery to normal apetite. This while providing equal or better immune-protection as compared to current emulsion vaccines. The polymeric emulsifier is a block copolymer having a general formula A-B-A in which component B is the divalent residue of a water-soluble polyalkylene glycol and component A is the residue of an oil-soluble complex monocarboxylic acid. Preferred emulsifier is a PEG-30-di-(polyhydroxystearate).