单-9-十八烯酸1,4:3,6-双脱水-D-甘露醇酯 | 52918-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 中文名称: 单-9-十八烯酸1,4:3,6-双脱水-D-甘露醇酯
• 英文名称: isomannide monooleate
• 英文别名: Unii-A2SV334fma；[(3R,3aR,6R,6aR)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (Z)-octadec-9-enoate
• CAS: 52918-93-1
• 化学式: C₂₄H₄₂O₅
• 分子量: 410.594
• InChiKey: JDRAOGVAQOVDEB-MGMRWDBRSA-N

物化性质

• 沸点：
  528℃
• 密度：
  1.04
• 闪点：
  169℃

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  29
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  油酸 在 对甲苯磺酸 作用下， 以 正己烷 、 水 、 甲苯 为溶剂， 生成 单-9-十八烯酸1,4:3,6-双脱水-D-甘露醇酯
  参考文献：
  名称：

  Water-in-oil adjuvant composition

  摘要：

  纯异甘油单油酸酯和纯铝单硬脂酸酯单独或组合使用，用于制备乳状型佐剂疫苗，以产生比采用商业甘油单油酸酯和铝单硬脂酸酯的现有佐剂更优越的佐剂。通过将纯铝单硬脂酸酯作为稳定剂与纯异甘油单油酸酯组合使用，可以获得高度理想的配方。

  公开号：

  US03983228A1

文献信息

• Green recyclable SO₃H-carbon catalyst for the selective synthesis of isomannide-based fatty acid monoesters as non-ionic bio-surfactants
  作者：T. Vijai Kumar Reddy、G. Sandhya Rani、R. B. N. Prasad、B. L. A. Prabhavathi Devi

  DOI：10.1039/c5ra03605d

  日期：——

  Solvent free one-pot synthesis of isomannide-based fatty acid monoesters as non-ionic bio-surfactants employing a green recyclable SO₃H-carbon catalyst was demonstrated.

  展示了一种无溶剂一锅法合成基于异甘醇的脂肪酸单酯作为非离子生物表面活性剂的方法，使用绿色可回收的SO₃H-碳催化剂。
• Herpes simplex type I fraction vaccine and process for its preparation
  申请人：Merck & Co., Inc.

  公开号：EP0048201A2

  公开（公告）日：1982-03-24

  A herpes simplex type I subunit vaccine is prepared from infected chick embryo cells by ultra extraction of the virus while the infected cells are still attached to the growth surface.

  I 型单纯疱疹亚单位疫苗是从受感染的鸡胚细胞中提取病毒的，当时受感染的细胞仍附着在生长表面。
• DNA sequences coding for avian coccidiosis antigens which induce a cell-mediated response, methods for their production, and vaccines containing them
  申请人：THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce

  公开号：EP0328253A2

  公开（公告）日：1989-08-16

  Disclosed are DNA sequences which code for antigenic proteins, methods for indentifying such DNA sequences, and antigens coded for by such DNA sequences. The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted to antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted to white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-­mediated immune response to avian coccidiosis. The DNA sequences of the present invention comprise cloned genes or fragments thereof that code on expression for antigenic protein that activates white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein.

  本发明公开了编码抗原蛋白的 DNA 序列、识别这种 DNA 序列的方法以及这种 DNA 序列编码的抗原。 该方法的第一步是提供多种 DNA 序列。然后将这些序列插入 DNA 表达载体，形成重组表达载体。将表达载体插入合适的宿主体内，形成表达 DNA 序列的转化体。然后将转化体与针对艾美耳抗原的抗体接触，以鉴定含有编码艾美耳抗原的 DNA 序列的转化体。这些抗原随后从被鉴定为编码抗原的 DNA 序列中产生。这样产生的抗原与白细胞接触，产生细胞介导的免疫反应，白细胞对抗原性艾美耳病蛋白敏感，从而鉴定出编码抗原的 DNA 序列，这些抗原可诱导对禽类球虫病的细胞介导的免疫反应。 本发明的 DNA 序列包括克隆基因或其片段，这些基因或片段在表达时编码能激活白细胞的抗原蛋白，从而产生细胞介导的免疫反应，这些白细胞对抗原性艾美耳病蛋白敏感。
• Peptides derived from the major allergen of ragweed (Ambrosia artemisiifolia) and uses thereof
  申请人：BIOMAY AG

  公开号：EP1958645A1

  公开（公告）日：2008-08-20

  The present invention relates to a peptide derived from the ragweed pollen allergen Amb a 1 and comprising 6 to 50 amino acid residues and pharmaceutical preparations comprising said peptide and uses thereof.

  本发明涉及一种源自豚草花粉过敏原 Amb a 1 并包含 6 至 50 个氨基酸残基的肽，以及包含所述肽的药物制剂及其用途。
• Hypoallergenic variants
  申请人：BIOMAY AG

  公开号：EP2110383A1

  公开（公告）日：2009-10-21

  The present invention relates to a hypoallergenic variant of the mugwort allergen Art v 1 (SEQ ID No. 1) or a fragment thereof, wherein the variant comprises at least one modification of at least one cysteine residue at amino acid positions 22, 26, 47 or 49 of SEQ ID No. 1.

  本发明涉及艾草过敏原Art v 1（SEQ ID No.1）的低过敏性变体或其片段，其中该变体包含对SEQ ID No.1的氨基酸位置22、26、47或49的至少一个半胱氨酸残基的至少一种修饰。