1-methyl-3-ethylindoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methyl-3-ethylindoline
• 英文别名: 3-ethyl-2,3-dihydro-1-methylindole；3-ethyl-1-methylindoline；3-ethyl-1-methyl-2,3-dihydroindole
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: HFVFAXGTMHTUQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴苯胺 在 甲基溴化镁 、 叔丁基锂 作用下， 以 四氢呋喃 、 乙醚 、 正庚烷 为溶剂， 反应 4.0h， 生成 1-methyl-3-ethylindoline
  参考文献：
  名称：

  Preparation of differentially 1,3-disubstituted indolines by intramolecular carbolithiation

  摘要：

  The ether-soluble dilithio species (2), derived from N-allyl-2-bromoaniline (1) upon treatment with t-BuLi at -78degreesC, cyclizes when warmed to +5degreesC in the presence of TMEDA to give a (l-lithio-3-indolinyl)methyllithium (3) that may be differentially functionalized by sequential addition of electrophiles. The cyclization of 2 to 3 proceeds enantioselectively when conducted in the presence of (1S,2S)-(+)-N,O-dimethylpseudoephedrine. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01204-8

文献信息

• Reductive Deamination with Hydrosilanes Catalyzed by B(C ₆ F ₅ ) ₃
  作者：Huaquan Fang、Martin Oestreich

  DOI：10.1002/anie.202004651

  日期：2020.7.6

  to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C−N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition‐metal‐free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and

  已知强硼路易斯酸三(五氟苯基)硼烷B(C 6 F 5 ) 3在高温下催化某些胺和氢硅烷的脱氢偶联。在较高温度下，脱氢途径与CN键的断裂竞争并获得去官能化。这可以成为一种有用的方法，用于多种胺以及异氰酸酯和异硫氰酸酯等杂积烯的无过渡金属还原脱氨。
• NOVEL COMPOUNDS
  申请人：Gottschling Dirk

  公开号：US20110195954A1

  公开（公告）日：2011-08-11

  The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R 1 , R 2 , R 3 and R 4 are defined as mentioned in the description, the tautomers thereof, the isomers thereof, the diastereomers thereof, the enantiomers thereof, the hydrates thereof, the mixtures thereof and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, the use thereof and processes for the preparation thereof.

  本发明涉及一般式I的新CGRP拮抗剂，其中U、V、X、Y、R1、R2、R3和R4如描述中所述定义，其互变异构体、异构体、顺反异构体、对映异构体、水合物、混合物及其盐，以及其盐的水合物，特别是与无机或有机酸或碱形成的生理上可接受的盐，包含这些化合物的药物、其用途以及其制备方法。
• Regioselective synthesis of substituted 1-indanols, 2,3-dihydrobenzofurans and 2,3-dihydroindoles by electrochemical radical cyclization using an arene mediator
  作者：Nobuhito Kurono、Eiichi Honda、Fumikazu Komatsu、Kazuhiko Orito、Masao Tokuda

  DOI：10.1016/j.tet.2003.12.038

  日期：2004.2

  Electrochemical reduction of haloarenes carrying 2-(1-hydroxybut-3-enyl), 2-allyloxy or N-allyl-N-methylamino group in the presence of phenanthrene as a mediator generated the corresponding aryl radicals and gave the corresponding 5-exo cyclization products in good yields. Higher regio- and stereoselectivities than those of usual radical cyclization using AIBN-Bu3SnH were achieved. (C) 2003 Elsevier Ltd. All rights reserved.
• UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1750704B1

  公开（公告）日：2009-07-22
• N-LINKED HETEROCYCLIC ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1896466B1

  公开（公告）日：2011-04-13