9-(4-methoxyphenyl)-6,6-dimethyl-4-p-tolyl-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-(4-methoxyphenyl)-6,6-dimethyl-4-p-tolyl-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione
• 英文别名: 9-(4-Methoxyphenyl)-6,6-dimethyl-4-(4-methylphenyl)-3,5,7,9-tetrahydrofuro[3,4-b]quinoline-1,8-dione；9-(4-methoxyphenyl)-6,6-dimethyl-4-(4-methylphenyl)-3,5,7,9-tetrahydrofuro[3,4-b]quinoline-1,8-dione
• 化学式: C₂₇H₂₇NO₄
• 分子量: 429.516
• InChiKey: DIUDJGORQTUCOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙烷,三氯氟- 在 copper(II) ferrite 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 3.0h， 生成 9-(4-methoxyphenyl)-6,6-dimethyl-4-p-tolyl-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione
  参考文献：
  名称：

  高活性磁性可分离CuFe 2 O 4纳米催化剂：绿色合成四氢呋喃[3,4-b]喹啉-1,8（3 H，4 H）二酮衍生物的有效催化剂

  摘要：

  摘要据报道，通过苯甲醛，1,3-环己烷二酮和苯胺内酯的缩合反应合成四氢呋喃并[3,4- b ]喹啉-1,8（3 H，4 H）-二酮的简便有效的方法。 CuFe 2 O 4作为在水中具有高催化活性的可重复使用的纳米催化剂的存在。该方法的显着优势是优异的分离产率，较短的反应时间，简单的后处理程序以及对环境的影响很小。 图形概要 。

  DOI：

  10.1007/s13738-014-0422-x

文献信息

• One-Pot Synthesis of N-Substituted Azapodophyllotoxin Derivatives under Microwave Irradiation
  作者：Shujiang Tu、Shunjun Ji、Yan Zhang、Bo Jiang、Runhong Jia、Junyong Zhang、Jinpeng Zhang

  DOI：10.1055/s-2006-950297

  日期：2006.11

  A series of new, N-substituted azapodophyllotoxin derivatives were synthesized via a three-component reaction of an aldehyde, an enaminone and tetronic acid in glacial acetic acid, under microwave irradiation, without a catalyst. This new protocol has the advantages of shorter time, higher yields, lower cost and broader substrate scope, as well as easier operation.

  通过醛、烯胺酮和特罗尼酸在冰醋酸中，在微波辐射下，无催化剂的三组分反应，合成了一系列新型 N 取代的氮杂鬼臼毒素衍生物。这种新协议具有时间更短、产量更高、成本更低、基材范围更广、操作更简单等优点。
• A multi-component reaction for the synthesis of N-substituted furo[3,4-b]quinoline derivatives under microwave irradiation
  作者：Shujiang Tu、Yan Zhang、Runhong Jia、Bo Jiang、Junyong Zhang、Shunjun Ji

  DOI：10.1016/j.tetlet.2006.07.035

  日期：2006.9

  A series of new N-substituted furo[3,4-b]quinoline derivatives were synthesized via a three-component reaction of an aldehyde, an enamineone and tetronic acid in glacial acetic acid under microwave irradiation without a catalyst. This new protocol has the advantages of shorter time, higher yields, lower cost and broader substrate scope, as well as easier operation. (c) 2006 Elsevier Ltd. All rights reserved.
• An efficient one-pot three-component synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione derivatives catalyzed by L-proline
  作者：Chun-Ling Shi、Hui Chen、Daqing Shi

  DOI：10.1002/jhet.782

  日期：2012.1

  AbstractL‐Proline is found to be an efficient catalyst for the synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives. This protocol is novel and has the advantages of mild condition, high yield, and easy operation. J. Heterocyclic Chem., (2012).
• Highly active magnetically separable CuFe2O4 nanocatalyst: an efficient catalyst for the green synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H) dione derivatives
  作者：Ramin Ghahremanzadeh、Zahra Rashid、Amir-Hassan Zarnani、Hossein Naeimi

  DOI：10.1007/s13738-014-0422-x

  日期：2014.10

  AbstractA facile and efficient procedure has been reported for the synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-diones by the condensation reaction of benzaldehydes, 1,3-cyclohexanediones and anilinolactones in the presence of CuFe2O4 as a reusable nanocatalyst with high catalytic activity in water. The notable advantages of this method are excellent isolated yields, short reaction times

  摘要据报道，通过苯甲醛，1,3-环己烷二酮和苯胺内酯的缩合反应合成四氢呋喃并[3,4- b ]喹啉-1,8（3 H，4 H）-二酮的简便有效的方法。 CuFe 2 O 4作为在水中具有高催化活性的可重复使用的纳米催化剂的存在。该方法的显着优势是优异的分离产率，较短的反应时间，简单的后处理程序以及对环境的影响很小。 图形概要 。