1-sinapoyl glycerol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1-sinapoyl glycerol
• 英文别名: 2,3-dihydroxypropyl (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate
• 化学式: C₁₄H₁₈O₇
• 分子量: 298.293
• InChiKey: DOTGUJUXRMTVLM-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,5-二甲氧基-4-羟基肉桂酸 、 甘油 在 acetate buffer 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以70%的产率得到1-sinapoyl glycerol
  参考文献：
  名称：

  Enzymatic Synthesis of Hydroxycinnamic Acid Glycerol Esters Using Type A Feruloyl Esterase fromAspergillus niger

  摘要：

  我们发现羟基肉桂酸（HA）甘油酯，如 1-鞘氨醇甘油酯和 1-对香豆酰甘油酯，可通过使用黑曲霉的 A 型阿魏酰酯酶进行直接酯化反应合成。HA 甘油酯的水溶性高于原始化学品。HA 甘油酯可吸收紫外线并清除 1,1-二苯基-2-苦基肼自由基。

  DOI：

  10.1271/bbb.70382

文献信息

• [EN] USE OF COMPOUNDS RESULTING FROM A SUGAR POLYOL OR FROM A DEHYDROGENATED SUGAR POLYOL DERIVATIVE AS A UV-SCREENING AGENT; ANTISUN COMPOSITIONS CONTAINING SAME; AND NOVEL COMPOUNDS<br/>[FR] UTILISATION DES COMPOSÉS OBTENUS À PARTIR D'UN POLYOL DE TYPE SUCRE OU D'UN DÉRIVÉ DÉSHYDROGÉNÉ DE POLYOL DE TYPE SUCRE À TITRE D'AGENT DE FILTRATION UV ; COMPOSITIONS ANTISOLAIRES LES CONTENANT ; ET NOUVEAUX COMPOSÉS
  申请人：OREAL

  公开号：WO2012010554A1

  公开（公告）日：2012-01-26

  The present invention relates to the cosmetic use, as an agent for screening out UV radiation, of compounds resulting from a sugar polyol or from a dehydrogenated sugar polyol derivative of formula (I) or (II) in which A1 and A2 denote UV-screening groups; Z1 and Z2 a sugar polyol group or a dehydrogenated sugar polyol derivative such that the product of formula (I) has in its structure from 1 to 4 -OH groups remaining and optionally from 1 to 2 -COOH groups. The present invention also relates to a composition comprising, in a cosmetically acceptable medium, at least one compound of formula (I) or (II). The present invention also relates to novel compounds resulting from a sugar polyol or from a dehydrogenated sugar polyol derivative of formula (I) or (II).

  本发明涉及一种化妆品用途，即作为筛选紫外线辐射的剂量，使用公式（I）或（II）的糖多醇或去氢糖多醇衍生物所得化合物，其中A1和A2表示紫外线筛选基团；Z1和Z2表示糖多醇基团或去氢糖多醇衍生物，使得公式（I）的产物在其结构中具有1-4个-OH基团和可选的1-2个-COOH基团。本发明还涉及一种组合物，其中包含在化妆品可接受介质中的至少一种公式（I）或（II）的化合物。本发明还涉及由公式（I）或（II）的糖多醇或去氢糖多醇衍生物所得的新化合物。
• Crocins Compounds and Uses Thereof
  申请人：Jinan University

  公开号：US20190177354A1

  公开（公告）日：2019-06-13

  Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H 2 O 2 ) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H 2 O 2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.
• Enzymatic Synthesis of Hydroxycinnamic Acid Glycerol Esters Using Type A Feruloyl Esterase from<i>Aspergillus niger</i>
  作者：Moriyasu TSUCHIYAMA、Tatsuji SAKAMOTO、Shinji TANIMORI、Shuichi MURATA、Haruhiko KAWASAKI

  DOI：10.1271/bbb.70382

  日期：2007.10.23

  We found that hydroxycinnamic acid (HA) glycerol esters such as 1-sinapoyl glycerol and 1-p-coumaroyl glycerol can be synthesized through a direct esterification reaction using a type A feruloyl esterase from Aspergillus niger. The water solubilities of HA glycerol esters were higher than those of the original chemicals. HA glycerol esters absorbed ultraviolet light and scavenged 1,1-diphenyl-2-picrylhydrazyl radicals.

  我们发现羟基肉桂酸（HA）甘油酯，如 1-鞘氨醇甘油酯和 1-对香豆酰甘油酯，可通过使用黑曲霉的 A 型阿魏酰酯酶进行直接酯化反应合成。HA 甘油酯的水溶性高于原始化学品。HA 甘油酯可吸收紫外线并清除 1,1-二苯基-2-苦基肼自由基。