Picrasane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Picrasane
• 英文别名: (1R,2S,6R,7S,9R,13S,14S,17S)-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.02,7.013,17]heptadecane
• 化学式: C₂₀H₃₄O
• 分子量: 290.5
• InChiKey: XKTUNHQVVRTGNO-XYQAPHKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Quassinoid compositions for the treatment of cancer and other proliferative diseases
  申请人：McChesney D. James

  公开号：US20060281807A1

  公开（公告）日：2006-12-14

  The invention provides quassinoid compounds that are useful in treating cancer. The invention further provides a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of killing a cancer cell, and a method of treating cancer in a mammal.

  这项发明提供了对治疗癌症有用的苦木酮类化合物。该发明还提供了一种包含药用载体和该发明中至少一种化合物的组合物，一种杀死癌细胞的方法，以及一种治疗哺乳动物癌症的方法。
• Therapeutic quassinoid preparations with antineoplastic, antiviral, and herbistatic activity
  申请人：Advanced Research & Technology Institute

  公开号：EP1325922A2

  公开（公告）日：2003-07-09

  The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.

  本发明包括纯化和分离出的类槲皮素以及基于皮康烷碳骨架合成的类槲皮素类似物。本发明还讨论了在 C-15 位加入水溶性物质（如甘氨酸）的新型侧链。此外，还公开了利用这些类槲皮素的抗癌、抗病毒和草药特性的治疗方法，包括用于治疗实体瘤和人类免疫缺陷病毒感染细胞。
• Compositions Comprising Fluoroolefins and Uses Thereof
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2295518A2

  公开（公告）日：2011-03-16

  The present invention relates to fluoroolefin compositions. The fluoroolefin compositions of the present invention are useful as refrigerants or heat transfer fluids and in processes for producing cooling or heat. Additionally, the fluoroolefin compositions of the present invention may be used to replace currently used refrigerant or heat transfer fluid compositions that have higher global warming potential.

  本发明涉及氟烯烃组合物。本发明的氟烯烃组合物可用作制冷剂或传热流体，也可用于产生冷却或热量的工艺中。此外，本发明的氟烯烃组合物可用来替代目前使用的全球变暖潜能值较高的制冷剂或导热油组合物。
• Terephthalate stabilizers for fluoroolefins
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2420546A2

  公开（公告）日：2012-02-22

  The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one terephthalate or a mixture thereof with at least one of ascorbic acid and nitromethane. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.

  本公开涉及由至少一种氟烯烃和有效量的稳定剂组成的组合物，稳定剂由至少一种对苯二甲酸盐或其混合物与抗坏血酸和硝基甲烷中的至少一种组成。这种稳定组合物可用于制冷、空调、冷风机和热泵等冷却设备，也可用作发泡剂、溶剂、气溶胶推进剂、灭火剂和消毒剂。
• Phosphorus-containing stabilizers for fluoroolefins
  申请人：E.I. Du Pont De Nemours And Company

  公开号：EP2410032A2

  公开（公告）日：2012-01-25

  The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one phosphorus-containing compound selected from the group consisting of thiophosphates, butylated triphenylphosphorothionates, and organophosphates. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.

  本公开涉及的组合物包含至少一种氟烯烃和有效量的稳定剂，稳定剂包含至少一种含磷化合物，该化合物选自由硫代磷酸盐、丁基化三苯基硫代磷酸盐和有机磷酸盐组成的组。这种稳定组合物可用于制冷、空调、冷却器和热泵等冷却设备，也可用作发泡剂、溶剂、气溶胶推进剂、灭火剂和消毒剂。