己酸,2-乙基-,44-羟基-3,6,9,12,15,18,21,24,27,30,33,36,39,42-十四氧杂四四十碳-1-基酯 | 5973-17-1

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物 - 酚及其卤化、磺化、硝化或亚硝化衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 己酸,2-乙基-,44-羟基-3,6,9,12,15,18,21,24,27,30,33,36,39,42-十四氧杂四四十碳-1-基酯
• 中文别名: 苯酚铵
• 英文名称: phenol amine
• 英文别名: Phenol.Ammoniak；azane;phenol
• CAS: 5973-17-1
• 化学式: C₆H₆O*H₃N
• 分子量: 111.144
• InChiKey: XABJJJZIQNZSIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.14
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Process for performing an isolated Pd(II)-mediated oxidation reaction
  申请人：Moeller D. Kevin

  公开号：US20060205959A1

  公开（公告）日：2006-09-14

  There is disclosed a process for performing an isolated Pd(II) mediated oxidation reaction electrochemically. The inventive process is performed on an electrode array device having a plurality of separately addressable electrodes. Preferably, the Pd(II) mediated oxidation is a Wacker reaction. Specifically, there is disclosed a process for conducting an isolated Pd(II) mediated oxidation on a plurality of electrodes, comprising providing an electrode array device having a plurality of electrodes with a conductive electrode surface and a matrix or coating material over the electrodes surfaces; providing a solution bathing the electrode array matrix or coating material and electrode surfaces, wherein the solution comprises a transition metal species and a confining agent; and biasing one or a plurality of electrodes (“selected electrode or electrodes”) with a voltage or current to regenerate the transition metal species required for the isolated Pd(II) mediated oxidation, whereby the confining agent limits diffusion of the transition metal species to a volume surrounding each selected electrode surface.

  所披露的是一种用电化学方法进行隔离的Pd(II)催化的氧化反应的过程。该发明过程是在具有多个独立寻址电极的电极阵列设备上进行的。优选地，Pd(II)催化的氧化是一种Wacker反应。具体来说，所披露的是一种在多个电极上进行的隔离Pd(II)催化的氧化过程，包括提供一个具有多个电极的电极阵列设备，电极具有导电电极表面和覆盖在电极表面的基质或涂层材料；提供一个溶液来浸泡电极阵列基质或涂层材料和电极表面，其中该溶液包含过渡金属物种和限制剂；以及偏置一个或多个电极（“选定电极或电极”）以电压或电流再生进行隔离Pd(II)催化的氧化所需的过渡金属物种，从而限制剂限制了过渡金属物种向包围每个选定电极表面的体积内的扩散。
• SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD
  申请人：Cheng T.W. Peter

  公开号：US20080009534A1

  公开（公告）日：2008-01-10

  Compounds are provided which have the structure of Formula (I): wherein R is hydrogen or C 1 -C 4 alkyl; and each of R 1 and R 2 is independently hydrogen, C 1 -C 4 alkyl, halo or C 1 -C 4 alkoxy, and salts thereof, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

  提供具有以下结构的化合物（I）：其中R为氢或C1-C4烷基；R1和R2中的每一个独立地为氢、C1-C4烷基、卤素或C1-C4甲氧基，以及它们的盐，这些化合物可用作抗糖尿病、降脂和抗肥胖药物。
• [EN] A PROCESS FOR THE PREPARATION OF ROTIGOTINE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LA ROTIGOTINE
  申请人：FIDIA FARMACEUTICI

  公开号：WO2010035111A1

  公开（公告）日：2010-04-01

  A process for the preparation of Rotigotine (I) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid- sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate (II) The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7,8-tetrahydro-6-(S)-N-propylamino-l-methoxy- naphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed.

  一种制备罗蒂高定（I）及其药用可接受盐的方法，包括将式6的胺与2-噻吩乙酸钠硼氢化合物进行还原胺化反应，并利用溴化氢盐5作为中间体（II）。该方法在工业角度具有优势，因为它允许从光学活性的5,6,7,8-四氢-6-(S)-N-丙基氨基-1-甲氧基-萘烯（2）出发，以高对映体纯度获得罗蒂高定，避免使用危险的反应物、需要困难的色谱分离或生成副产物。此外，还披露了两种新的结晶形式。
• PROCESS FOR THE PREPARATION OF ROTIGOTINE
  申请人：Banfi Aldo

  公开号：US20110230541A1

  公开（公告）日：2011-09-22

  A process for the preparation of Rotigotine (I) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid-sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate (II) The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7,8-tetrahydro-6-(S)-N-propylamino-1-methoxy-naphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed.

  一种制备罗蒂高定（I）及其药用可接受盐的方法，包括将式6的胺与2-噻吩乙酸-硼氢化钠复合物进行还原胺化反应，并利用溴化氢盐5作为中间体（II）。该方法在工业角度上具有优势，因为它允许从光学活性的5,6,7,8-四氢-6-(S)-N-丙基氨基-1-甲氧基-萘烯（2）出发，以高对映体纯度获得罗蒂高定，避免使用危险的反应物、需要困难的色谱分离或生成副产物。此外，还披露了两种新的结晶形式。
• Multinuclear half metallocene catalyst and method for preparing syndiotactic polystyrene using the same
  申请人：LG Chem Ltd.

  公开号：EP1777230A1

  公开（公告）日：2007-04-25

  Diclosed is a multinuclear transition metal half metallocene catalyst having a multinuclear half metallocene structure in which a transition metal of groups 3 to 10 on periodic table is connected to a cycloalkandienyl group or its derivative group on a side and also connected to phenol or phenolamine compound having a plurality of binding sites on another side. The metallocene catalyst is useful to produce syndiotatic styrene polymer having superior steroreguality, high melting point and broad molecular weight distribution with high activity together with a small amount of a cocatalyst. Further disclosed is a method for preparing styrene polymers using the same catalyst.

  披露了一种多核过渡金属半茂金属烯催化剂，其具有多核半茂金属烯结构，其中周期表3至10族的过渡金属连接到一个环戊二烯基团或其衍生物基团一侧，并且连接到另一侧具有多个结合位点的酚或酚胺化合物。这种茂金属烯催化剂可用于生产具有优越的立体构型、高熔点和宽分子量分布的顺反式苯乙烯聚合物，同时还需要少量的共催化剂。还公开了一种使用相同催化剂制备苯乙烯聚合物的方法。