4-[[4-(Diethylcarbamoyl)phenyl]-[1-(pyridin-2-ylmethyl)piperidin-4-ylidene]methyl]benzamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-[[4-(Diethylcarbamoyl)phenyl]-[1-(pyridin-2-ylmethyl)piperidin-4-ylidene]methyl]benzamide
• 化学式: C₃₀H₃₄N₄O₂
• 分子量: 482.6
• InChiKey: PYCWETIRCZZOCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPIOD RECEPTOR AGONISTS<br/>[FR] DERIVES DE DIARYLMETHYLIDENE PIPERIDINE ET LEUR UTILISATION COMME AGONISTES DU RECEPTEUR OPIOIDE DELTA
  申请人：ASTRAZENECA AB

  公开号：WO2004101520A1

  公开（公告）日：2004-11-25

  Compounds of general formula: (Formula (I)) wherein R1, R2, R3, R4 and R5 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain and anxiety.

  通式化合物：（化学式（I））其中R1、R2、R3、R4和R5如规范中定义，以及相应的盐、对映体和包括这些化合物的药物组成物已经制备。它们在治疗中很有用，特别是在疼痛和焦虑管理方面。
• Diarylmethylidene piperidine derivatives and their use as delta opiod receptor agonists
  申请人：Brown William

  公开号：US20070066655A1

  公开（公告）日：2007-03-22

  Compounds of general formula: (Formula (I)) wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain and anxiety.

  通式为(Formula (I))的化合物，其中R1、R2、R3、R4和R5如规范中所定义，以及所述化合物的盐、对映体和包括所述化合物的药物组成物已被制备。它们在治疗中有用，特别是在疼痛和焦虑管理方面。
• DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPIOID RECEPTOR AGONISTS
  申请人：AstraZeneca AB

  公开号：EP1626960A1

  公开（公告）日：2006-02-22