(R)-1-(2,6-二氯苯基)乙胺盐酸盐 | 1131737-05-7

• 物质功能分类: 有机原料 - 氨基化合物 - 环烷胺、芳香单胺、芳香多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (R)-1-(2,6-二氯苯基)乙胺盐酸盐
• 英文名称: (R)-1-(2,6-dichlorophenyl)ethanamine hydrochloride
• 英文别名: (1R)-1-(2,6-dichlorophenyl)ethanamine;hydrochloride
• CAS: 1131737-05-7
• 化学式: C8H10Cl3N
• 分子量: 226.5
• InChiKey: QBWKCUFYMDZATP-NUBCRITNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• SUBSTITUTED IMIDAZOLE SALT COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF
  申请人：Xiamen Vivohealths Technology Co., Ltd.

  公开号：EP3608312A1

  公开（公告）日：2020-02-12

  Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:

  本发明公开了一种具有醛缩酶选择性抑制活性的化合物、其制备方法、包含这些化合物的药物组合物，以及这些化合物在制造用于抑制甘油三酯和胆固醇合成、减少脂肪酸合成、预防和/或治疗肥胖症和II型糖尿病、预防和/或治疗肿瘤、预防和/或治疗帕金森病、预防和/或治疗阿尔茨海默病或延长哺乳动物寿命的药物中的用途：
• SUBSTITUTED IMIDAZOLE SALT COMPOUNDS, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF
  申请人：Xiamen Vivohealths Technology Co., Ltd.

  公开号：US20200109122A1

  公开（公告）日：2020-04-09

  Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals: