(2R)-N-methylsulfonyl-2-[4-(pyrrolidin-1-ylmethyl)phenyl]propanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2R)-N-methylsulfonyl-2-[4-(pyrrolidin-1-ylmethyl)phenyl]propanamide
• 化学式: C₁₅H₂₂N₂O₃S
• 分子量: 310.4
• InChiKey: PQWRRALVRZHAGC-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• AMIDES OF R-2-(AMINOARYL)-PROPIONIC ACIDS FOR USE IN THEPREVENTION OF LEUCOCYTE ACTIVATION"
  申请人：Dompé S.P.A.

  公开号：EP1276732A1

  公开（公告）日：2003-01-22
• [EN] "AMIDES OF R-2-(AMINOARYL)-PROPIONIC ACIDS FOR USE IN THEPREVENTION OF LEUCOCYTE ACTIVATION"<br/>[FR] AMIDES D'ACIDES R-2-(AMINOARYL)-PROTONIQUES PREVENANT L'ACTIVATION DES LEUCOCYTES
  申请人：DOMPE SPA

  公开号：WO2001079189A2

  公开（公告）日：2001-10-25

  N-(2-aminoaryl-propionyl)-amides of formula (1) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of 2-(aminoaryl)-propionyl amides of formula (1) for use in the inhibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.