5-(Dithiolan-3-yl)-3-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: 5-(Dithiolan-3-yl)-3-oxopentanoic acid
• 化学式: C₈H₁₂O₃S₂
• 分子量: 220.3
• InChiKey: WLBFJIOVMCMJMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] THIONE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME<br/>[FR] DERIVES DE THIONE, LEURS PROCEDES DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：CJ CORP

  公开号：WO2005051941A1

  公开（公告）日：2005-06-09

  A 1,2,4-triazole derivative of formula (1) or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

  本发明提供了一种式(1)的1,2,4-三唑衍生物或其非毒性盐，其制备方法以及含有该衍生物或盐作为活性成分的药物组合物。
• Thione Derivative, Method For The Preparation Thereof, And Pharmaceutical Composition Containing The Same
  申请人：Cho Il Hwan

  公开号：US20080090875A1

  公开（公告）日：2008-04-17

  A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

  提供了公式1的1,2,4-三唑衍生物或其非毒性盐的制备方法，以及含有该衍生物或盐作为活性成分的药物组合物。
• LIPOIC ACID METABOLITE: USEFUL FOR DRUG CARRIER, NANOPARTICLE CONJUGATE, IMAGING AND HYPERTHERMIA THERAPY
  申请人：Seetharama Ravikumar Kabyadi

  公开号：US20110250132A1

  公开（公告）日：2011-10-13

  The present invention relates to simultaneous tracking or imaging followed by hyperthermia therapy for cancer and other diseases associated with altered metabolic enzymes. In particular, the invention relates to a novel class of therapeutic nanomaterial which selectively target and kill tumor cells.

  本发明涉及同时跟踪或成像后进行高温疗法治疗癌症和其他与代谢酶改变相关的疾病。特别地，本发明涉及一种新型的治疗性纳米材料，可以选择性地靶向和杀死肿瘤细胞。
• LIPOIC ACID METABOLITE CONJUGATE: PREPARATION AND THEIR THERAPEUTIC EFFECT
  申请人：Seetharama Ravikumar Kabyadi

  公开号：US20110251138A1

  公开（公告）日：2011-10-13

  The present invention is a design and synthesis of a series of therapeutic conjugates which consists of tautomers of lipoic acid metabolites, with small molecule, vitamin, carbohydrates, peptides, chemotherapeutic agent wherein or not the conjugate possesses dual binding ability. The present invention can be used to therapeutics and diagnostics in vitro for cancer and other diseases associated with altered metabolic enzymes. The invention can also be used for the controlled release of more stable form of lipoic acid in its salt form with the minerals or vitamins.
• US7781592B2
  申请人：——

  公开号：US7781592B2

  公开（公告）日：2010-08-24