2-[4-(3-phenoxyphenyl)butyl]-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]propanedioic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[4-(3-phenoxyphenyl)butyl]-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]propanedioic acid
• 化学式: C₃₄H₄₄O₅
• 分子量: 532.7
• InChiKey: RHKPSSZICVTZLH-FBXQPAQYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  39
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• REMEDY FOR XANTHOMA
  申请人：National University Corp. Kobe University

  公开号：EP1889632A1

  公开（公告）日：2008-02-20

  A preventive/remedy for xanthoma which contains a compound having an inhibitory effect on squalene synthase, its prodrug or its salt.

  一种黄疽的预防/治疗方法，其中含有一种对角鲨烯合成酶有抑制作用的化合物、其原药或其盐。
• Skeletal muscle protecting agent
  申请人：Tozawa Ryuichi

  公开号：US20080113965A1

  公开（公告）日：2008-05-15

  The present invention provides a novel drug which is useful as a skeletal muscle protecting agent comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
• Crp Lowering Agent
  申请人：Imura Yoshimi

  公开号：US20090118255A1

  公开（公告）日：2009-05-07

  The present invention provides a novel drug which is useful as a preventive and/or therapeutic agent for various diseases involved in elevation of CRP level, in particular, inflammatory disease and cancer comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
• Novel Method of Treating Hyperlipidemia
  申请人：Nishimoto Tomoyuki

  公开号：US20090209510A1

  公开（公告）日：2009-08-20

  A pharmaceutical composition useful for a prevention and/or treatment of hyperlipidemia, which comprises combining an effective amount of squalene synthase inhibitor and HMG-CoA reductase inhibitor is provided.
• [EN] NOVEL METHOD OF TREATING HYPERLIPIDEMIA<br/>[FR] NOUVELLE METHODE DE TRAITEMENT DE L'HYPERLIPIDEMIE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2006129859A2

  公开（公告）日：2006-12-07

  [EN] A pharmaceutical composition useful for a prevention and/or treatment of hyperlipidemia, which comprises combining an effective amount of squalene synthase inhibitor and HMG-CoA reductase inhibitor is provided.
  [FR] L'invention porte sur une composition pharmaceutique utile dans la prévention et/ou le traitement de l'hyperlipidémie. Cette composition comprend une combinaison d'une quantité efficace d'un inhibiteur de la squalène synthase et d'un inhibiteur de la HMG-CoA réductase.