3-(2-dimethylaminomethyl-cyclohex-1-enyl)-phenyl 2-(4-isobutyl-phenyl)-propionate | 269079-60-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-(2-dimethylaminomethyl-cyclohex-1-enyl)-phenyl 2-(4-isobutyl-phenyl)-propionate
• 英文别名: [3-[2-[(Dimethylamino)methyl]cyclohexen-1-yl]phenyl] 2-[4-(2-methylpropyl)phenyl]propanoate
• CAS: 269079-60-9
• 化学式: C₂₈H₃₇NO₂
• 分子量: 419.607
• InChiKey: YSSBPECAUUPTPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
  申请人：——

  公开号：US20030100598A1

  公开（公告）日：2003-05-29

  New esters derived from substituted phenyl-cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analgesic activity, a lower toxicity and a longer effective time period than Tramadol.

  新的酯类化合物来源于取自曲马多（Tramadol）的取代苯基-环己基化合物，其制备方法以及它们用于制备具有镇痛性质的药物。这些新化合物的通式（I）具有比曲马多更高的镇痛活性，更低的毒性和更长的有效时间。
• NEW ESTERS DERIVED FROM SUBSTITUTED PHENYL-CYCLOHEXYL COMPOUNDS
  申请人：VITA-INVEST, S.A.

  公开号：EP1127871A1

  公开（公告）日：2001-08-29

  New csters derived from substituted phenyl cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analges activcity, a lower toxicity and a longer effective time period than Tramadol.

  从曲马多衍生的取代苯基环己基化合物的新酯类、获得过程及其在制备具有镇痛特性的药物中的用途。与曲马多相比，这些通式（I）的新化合物具有更高的镇痛活性、更低的毒性和更长的有效期。
• New esters derived from substituted phenyl-cyclohexyl compounds
  申请人：VITA-INVEST, S.A.

  公开号：EP1219594A1

  公开（公告）日：2002-07-03

  New esters derived from substituted phenylcyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analgesic activity, a lower toxicity and a longer effective time period than Tramadol.

  由取代苯基环己基化合物衍生的新酯类，这些化合物是从曲马多衍生出来的，它们的获得过程以及它们在制备具有镇痛特性的药物中的用途。与曲马多相比，这些通式（I）的新化合物具有更高的镇痛活性、更低的毒性和更长的有效期。
• Abuse-proofed dosage form
  申请人：GRÜNENTHAL GMBH

  公开号：US10058548B2

  公开（公告）日：2018-08-28

  The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

  本发明涉及一种热成型而不变色并可防止滥用的剂型，它包括至少一种断裂强度至少为 500 N 的合成或天然聚合物，以及一种或多种可能被滥用的活性物质。本发明还涉及生产上述剂型的相应方法。
• Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
  申请人：GRÜNENTHAL GMBH

  公开号：US10064945B2

  公开（公告）日：2018-09-04

  A thermoformed, tamper-resistant pharmaceutical dosage form comprises: a) a pharmacologically active ingredient; b) a polyalkylene oxide having a weight average molecular weight of more than 200,000 g/mol; and c) a zinc component, wherein the content of said zinc component is at least 1 ppm, relative to the total weight of the pharmaceutical dosage form. When the pharmacologically active ingredient is effective against pain, the pharmaceutical dosage form may be used in a method of treating pain. When the pharmacologically active ingredient has abuse potential, the pharmaceutical dosage form may be used in a method of reducing the incidence of the abuse of said pharmacologically active ingredient.

  一种热成型防篡改药物剂型包括 a) 药理活性成分； b) 聚环氧烷，其重量平均分子量大于 200,000 克/摩尔；以及 c) 锌成分，其中所述锌成分的含量相对于药物剂型的总重量至少为 1 ppm。 当药理活性成分对疼痛有效时，药物剂型可用于治疗疼痛的方法。当药理活性成分具有滥用潜力时，药物剂型可用于降低所述药理活性成分滥用发生率的方法。