5-(3-hydroxy-3,7,11,15-tetramethyl-6(E),10(E),14-hexadecatrienyl)-2,3-dimethyl-2,5-cyclohexadiene-1,4-dione | 152369-68-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5-(3-hydroxy-3,7,11,15-tetramethyl-6(E),10(E),14-hexadecatrienyl)-2,3-dimethyl-2,5-cyclohexadiene-1,4-dione
• 英文别名: 5-[(6E,10E)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl]-2,3-dimethylcyclohexa-2,5-diene-1,4-dione
• CAS: 152369-68-1
• 化学式: C₂₈H₄₂O₃
• 分子量: 426.64
• InChiKey: XDAYAKKADGUIFP-NTZRDTQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
  申请人：BioElectron Technology Corporation

  公开号：US10029971B2

  公开（公告）日：2018-07-24

  A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans.

  一种生产α-生育三烯酚醌或其立体异构体的方法，该方法包括通过用金属盐氧化剂氧化α-生育三烯酚，在存在非α-生育三烯酚色烷的情况下，选择性地将α-生育三烯酚色烷开成α-生育三烯酚醌，其中金属盐氧化剂/α-生育三烯酚的化学计量比至少为4：其中，金属盐氧化剂/α-生育三烯酚的化学计量比至少为 4:1，并且所述金属氧化剂以顺序添加的方式加入，以减少起始α-生育三烯酚色烷材料中可能存在的任何数量的非α-生育三烯酚色烷的氧化。该工艺使用的条件有利于α-生育三烯酚色满与非α-生育三烯酚色满的氧化率。
• Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones
  申请人：BioElectron Technology Corporation

  公开号：US10195161B2

  公开（公告）日：2019-02-05

  The present invention relates to methods of treating Leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease.

  本发明涉及用生育三烯酚醌（包括α-生育三烯酚醌）治疗勒伯遗传性视神经病变和显性视神经萎缩的方法，以减轻该疾病的症状。
• TREATMENT OF LEBER'S HEREDITARY OPTIC NEUROPATHY AND DOMINANT OPTIC ATROPHY WITH TOCOTRIENOL QUINONES
  申请人：BIOELECTRON TECHNOLOGY CORPORATION

  公开号：EP2424495B1

  公开（公告）日：2018-01-17
• METHODS FOR SELECTIVE OXIDATION OF ALPHA TOCOTRIENOL IN THE PRESENCE OF NON-ALPHA TOCOTRIENOLS
  申请人：BIOELECTRON TECHNOLOGY CORPORATION

  公开号：EP2734512B1

  公开（公告）日：2019-11-20
• TREATMENT OF METHYLMALONIC ACIDURIA, ISOVALERIC ACIDURIA, AND OTHER ORGANIC ACIDURIAS WITH TOCOTRIENOL QUINONES
  申请人：PTC Therapeutics, Inc.

  公开号：EP2729004B1

  公开（公告）日：2020-03-25