2-[(6S)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[(6S)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
• 化学式: C₂₁H₃₀O₂
• 分子量: 314.5
• InChiKey: QHMBSVQNZZTUGM-QNSVNVJESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] AMORFRUTIN ANALOGS AS PPARGAMMA-MODULATORS<br/>[FR] ANALOGUES DE L'AMORFRUTINE EN TANT QUE MODULATEURS DE PPARGAMMA
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V

  公开号：WO2014177593A1

  公开（公告）日：2014-11-06

  The present invention relates to Amorfrutin analogues and stereoisomeric forms, solvates, hydrates, conjugates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these Amorfrutin analogues together with pharmaceutically acceptable carrier, excipient and/or diluents. Said Amorfrutin analogues have been identified as modulators of the peroxisome proliferator-activated receptors (PPARs), especially PPARϒ and are useful for the prevention and treatment of metabolic diseases, inflammatory diseases, cancer and preparation of phytomedicals and/or functional food products for prevention of metabolic diseases.

  本发明涉及Amorfrutin类似物和立体异构体形式，以及这些化合物的溶剂结晶体、水合物、结合物和/或药用可接受的盐，以及包含至少一种这些Amorfrutin类似物的药物组合物，与药用可接受的载体、赋形剂和/或稀释剂。所述的Amorfrutin类似物已被确定为过氧化物酶增殖物活化受体（PPARs）的调节剂，特别是PPARϒ，并且对于预防和治疗代谢性疾病、炎症性疾病、癌症以及制备植物药和/或功能性食品产品以预防代谢性疾病是有用的。
• [EN] PROCESS FOR THE PRODUCTION OF CANNABIDIOL AND DELTA-9-TETRAHYDROCANNABINOL<br/>[FR] PROCÉDÉ POUR LA PRODUCTION DE CANNABIDIOL ET DE DELTA-9-TÉTRAHYDROCANNABINOL
  申请人：NORAMCO INC

  公开号：WO2017011210A1

  公开（公告）日：2017-01-19

  The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.

  本公开涉及一种制备大麻二酚化合物或其衍生物的方法。该大麻二酚化合物或其衍生物可通过适当选择和取代的二卤代欧利芙酮或其衍生物与适当选择和取代的环烯烃进行酸催化反应制备得到，从而产生二卤代大麻二酚化合物或其衍生物。该二卤代大麻二酚化合物或其衍生物可高产率、高立体特异性或两者兼备地生产。然后，它可以在还原条件下转化为大麻二酚化合物或其衍生物。
• PROCESS FOR THE PRODUCTION OF CANNABIDIOL AND DELTA-9-TETRAHYDROCANNABINOL
  申请人：Noramco, Inc.

  公开号：EP3319952B1

  公开（公告）日：2020-02-05
• [EN] AEROSOLISABLE MATERIAL<br/>[FR] MATÉRIAU AÉROSOLISABLE
  申请人：NICOVENTURES TRADING LTD

  公开号：WO2021069908A1

  公开（公告）日：2021-04-15

  An aerosolisable material comprising (+)-cannabidiol and at least one carrier constituent.