2-Oxo-4-phenyl-5-tridecyl-tetrahydro-furan-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-Oxo-4-phenyl-5-tridecyl-tetrahydro-furan-3-carboxylic acid
• 英文别名: 2-Oxo-4-phenyl-5-tridecyloxolane-3-carboxylic acid
• 化学式: C₂₄H₃₆O₄
• 分子量: 388.547
• InChiKey: UUDKQPQGMOGQDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  28
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Oxo-4-phenyl-5-tridecyl-tetrahydro-furan-3-carboxylic acid 在 聚合甲醛 、 sodium acetate 、 溶剂黄146 、 N-甲基苯胺 作用下， 反应 11.0h， 以78%的产率得到dihydro-3-methylene-4-phenyl-5-tridecyl-2(3H)-furanone
  参考文献：
  名称：

  An Improved Procedure for α-Methylenation of Lactones

  摘要：

  A variety of gamma-butyrolactones, as well as a delta-valerolactone and an ester, have been efficiently converted to their alpha-methylene derivatives by using an improved decarboxylative methylenation procedure, which is simpler and more general than the previously described method.

  DOI：

  10.1080/00397919308009804
• 作为产物：
  描述：

  二氧化碳 、 4-Phenyl-5-tridecyl-dihydro-furan-2-one 在 lithium diisopropyl amide 作用下， 生成 2-Oxo-4-phenyl-5-tridecyl-tetrahydro-furan-3-carboxylic acid
  参考文献：
  名称：

  An Improved Procedure for α-Methylenation of Lactones

  摘要：

  A variety of gamma-butyrolactones, as well as a delta-valerolactone and an ester, have been efficiently converted to their alpha-methylene derivatives by using an improved decarboxylative methylenation procedure, which is simpler and more general than the previously described method.

  DOI：

  10.1080/00397919308009804